Registration Dossier
Registration Dossier
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EC number: 235-795-5 | CAS number: 12738-64-6
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- genetic toxicity in vitro, other
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1986
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- other: SISD Assessment report
- Title:
- Unnamed
- Year:
- 2 001
- Report date:
- 2001
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 479 (Genetic Toxicology: In Vitro Sister Chromatid Exchange Assay in Mammalian Cells)
- GLP compliance:
- not specified
- Type of assay:
- sister chromatid exchange assay in mammalian cells
Test material
- Reference substance name:
- Benzoic acid
- EC Number:
- 200-618-2
- EC Name:
- Benzoic acid
- Cas Number:
- 65-85-0
- Molecular formula:
- C7H6O2
- IUPAC Name:
- benzoic acid
- Test material form:
- not specified
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- lymphocytes: human
- Metabolic activation:
- without
- Test concentrations with justification for top dose:
- 0 to 2.0 mM
Results and discussion
Test results
- Key result
- Species / strain:
- lymphocytes: human
- Metabolic activation:
- without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
Applicant's summary and conclusion
- Conclusions:
- The genotixicity of benzoic acid was tested in human lymphocytes by sister cromatid exhange assay according to OECD 479. Doses from 0 to 2 mM was tested without metabolic activation. No genotoxicty was observed. The study is described in SIDS (2001)
- Executive summary:
The genotixicity of benzoic acid was tested in human lymphocytes by sister cromatid exhange assay according to OECD 479. Doses from 0 to 2 mM was tested without metabolic activation. No genotoxicty was observed. The study is described in SIDS (2001)
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