undecan-2-one; methyl nonyl ketone

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Justification for type of information:

Experimental test result performed using standard test guidelines

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

GLP compliance:

no

Type of method:

other: spectrophotometric analytical method

Key result

Water solubility:

79.86 mg/L

Conc. based on:

test mat.

Temp.:

25 °C

Remarks on result:

other: No other detail available

observation -

Sample stirring (h)	Concentration obtained		Average	Absorbance	Average	Dilution factor	Water Solubility value obtained (mg/L)	Average
24 h	R1	78.07	77.97	0.22	0.22	-	78.07	77.97
	R2	77.86		0.21			77.86
48 h	R1	78.82	79.18	0.22	0.22	-	78.82	79.18
	R2	79.54		0.22			79.54
72 h	R1	81.68	82.42	0.23	0.23	-	81.68	82.42
	R2	83.16		0.23			83.16

CALCULATION

The water solubility for 24 h, 48 h and 72 h was calculated as follows: Mean water solubility value for 24 h + 48 h + 72 h run sample.

= (77.97 + 79.18 + 82.42)/3

= 79.86 mg/L

Conclusions:

The water solubility determination of test chemical was done as per the OECD guideline 105 by spectrophotometric analytical method as per OECD 101. The solubility of test chemical in water was determine to be79.86 mg/L at 25°C.
Thus the test chemical is considered to be slightly soluble.

Executive summary:

The study was conducted to determine the solubility of test chemical in ultra-pure water, according to the OECD guideline 105 (Adopted by the Council on 27th July 1995) and OECD 101(Adopted: 12 May 1981). Test was conducted at 25±2 °C in two stages; preliminary testfor 24 h, followed by confirmatory test for 24 h, 48 h and 72 h in replicates. The final water solubility value was calculated based on average of the individual values obtained after 24 h, 48 h and 72 h. The difference between the average values in three vessels was not observed more than 15%. The water solubility value was observed to be79.86 mg/L at 25±2°C. Thus the test chemical  is considered to be slightly soluble.

Description of key information

The water solubility determination of test chemical  was done as per the OECD guideline 105 by spectrophotometric analytical method as per OECD 101. The solubility of test chemical in water was determine to be79.86 mg/L at 25°C.

Thus the test chemical  is considered to be slightly soluble.

Key value for chemical safety assessment

Water solubility:

79.86 mg/L

at the temperature of:

25 °C

Additional information

The study was conducted to determine the solubility of test chemical in ultra-pure water, according to the OECD guideline 105 (Adopted by the Council on 27th July 1995) and OECD 101(Adopted: 12 May 1981). Test was conducted at 25±2 °C in two stages; preliminary testfor 24 h, followed by confirmatory test for 24 h, 48 h and 72 h in replicates. The final water solubility value was calculated based on average of the individual values obtained after 24 h, 48 h and 72 h. The difference between the average values in three vessels was not observed more than 15%. The water solubility value was observed to be79.86 mg/L at 25±2°C.Thus the test chemical  is considered to be slightly soluble.