Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 214-071-2 | CAS number: 1077-28-7
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 11/1973 - 12/1973
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 974
- Report date:
- 1974
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- OECD 401: at least 5 rodents of each sex in each group; at least three dose levels; limit test at least 2000 mg/kg b.w. This Study: 10 rats of each sex in each group; 6 dose levels, spaced with factor 1.26
- GLP compliance:
- not specified
- Test type:
- standard acute method
Test material
- Reference substance name:
- 5-(dithiolan-3-yl)valeric acid
- EC Number:
- 214-071-2
- EC Name:
- 5-(dithiolan-3-yl)valeric acid
- Cas Number:
- 1077-28-7
- Molecular formula:
- C8H14O2S2
- IUPAC Name:
- 5-(1,2-dithiolan-3-yl)pentanoic acid
- Reference substance name:
- unknown
- IUPAC Name:
- unknown
- Reference substance name:
- Water
- EC Number:
- 231-791-2
- EC Name:
- Water
- Cas Number:
- 7732-18-5
- Molecular formula:
- H2O
- IUPAC Name:
- dihydrogen oxide
- Test material form:
- solid: bulk
- Details on test material:
- This composition is the usual techical grade of AlzChem AG. It will be used when test substance has this composition (or is very closed) or no specific information is available
Constituent 1
impurity 1
impurity 2
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Surviving animals were held in macrolon cages (B II) at 24.0 +/- 0.5 °c and 60 +/- 3 % relative humidity.
During 4 weeks after treatment behaviour, feed and water intake and body weigth were observed.
After 4 weeks animals were dissectet and examinded macroscopic.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: 1 % aequous methyl-hydroxyethylcellulose gel MH300
- Doses:
- Lowest dose: 504 mg/kg b.w.
Step per dose: factor 1.26
Highest dose: 1590 mg/kg b.w. - No. of animals per sex per dose:
- 10
- Control animals:
- no
- Statistics:
- Litchfield and Wilcoxon
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- ca. 1 190 mg/kg bw
- Based on:
- test mat.
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- ca. 1 210 mg/kg bw
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- Median lethal dose (LD50)
- Male rats: 1190 (1090 - 1300) mg/kg b.w.
- Female rats: 1210 (1110 - 1320) mg/kg b.w. - Executive summary:
Symptoms of intoxication showed:
- Sedation
- ataxis (635 mg/kg b.w.)
- reduced feed intake (1000 mg/kg b.w.)
- abdominal position
- slow and breathing
- tonic-clonic spasms (1260 mg/kg b.w.)
Death occured within 2 and 24 h after after treatment after tonic-clonic spasms.
Lowest lethal dose: 1000 mg/kg b.w.
Surviving animals recovered within 2 d.
Necopsy showed pale and parencymatic organs in animals that died after treatment. Other animals showed no pahological findings.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
