Octan-3-ol

Endpoint summary

Description of key information

Skin Irritation:

3-octanol was irritating to rabbit skin after 24 hours exposure.

Eye Irritation:

The ocular irritation potential of Octan-3-ol was estimated using OECD QSAR toolbox version 3.3 with logPow as the primary descriptor.

Octan-3-ol was estimated to be irritating to the eyes of rabbits.

Based on the estimated result; Octan-3-ol can be considered irritating to the eyes and can be classified under the category “Category 2” as per CLP regulation.

Key value for chemical safety assessment

Skin irritation / corrosion

Link to relevant study records

Reference

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Justification for type of information:

data is from peer reviewed journals and hasndbooks

Qualifier:

according to guideline

Guideline:

other: as mentioned below

Principles of method if other than guideline:

To assess the irritation potential of 3-octanol in rabbits

GLP compliance:

not specified

Specific details on test material used for the study:

- Name of test material: 3-Octanol
- IUPAC name: Octan-3-ol
- Molecular formula: C8H18O
- Molecular weight: 130.229 g/mole
- Smiles Notation: C([C@@H](CC)O)CCCC
- InChl: 1S/C8H18O/c1-3-5-6-7-8(9)4-2/h8-9H,3-7H2,1-2H3
- Substance type: Organic
- Physical state: Colorless Liquid

Species:

rabbit

Strain:

not specified

Details on test animals or test system and environmental conditions:

no data available

Type of coverage:

occlusive

Preparation of test site:

other: intact and abraded

Vehicle:

unchanged (no vehicle)

Controls:

not specified

Amount / concentration applied:

100% undiluted

Duration of treatment / exposure:

24 hours

Observation period:

24 hours

Number of animals:

no data available

Details on study design:

no data available

Irritation parameter:

overall irritation score

Basis:

mean

Time point:

24 h

Reversibility:

not specified

Remarks on result:

positive indication of irritation

Irritant / corrosive response data:

Moderately irritating to skin

Interpretation of results:

Category 2 (irritant) based on GHS criteria

Conclusions:

3-octanol was irritating to rabbit skin after 24 hours exposure.

Executive summary:

A skin irritation study was performed in rabbits to assess the irritation potential of 3-octanol. 3-octanol was applied undiluted to the intact and abraded skin of rabbits under occlusion. The rabbits were observed for signs of irritation till 24 hours. 3-octanol was irritating to rabbit skin after 24 hours exposure.

Endpoint conclusion

Endpoint conclusion:

adverse effect observed (irritating)

Eye irritation

Link to relevant study records

Reference

Endpoint:

eye irritation: in vivo

Type of information:

(Q)SAR

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification

Justification for type of information:

data is from OECD QSAR toolbox v3.3 and the QMRF report has been attached

Qualifier:

according to guideline

Guideline:

other: Estimated data

Principles of method if other than guideline:

Prediction was done using OECD QSAR toolbox v3.3

GLP compliance:

not specified

Specific details on test material used for the study:

- Name of test material: 3-Octanol
- IUPAC name: Octan-3-ol
- Molecular formula: C8H18O
- Molecular weight: 130.229 g/mole
- Smiles Notation: C([C@@H](CC)O)CCCC
- InChl: 1S/C8H18O/c1-3-5-6-7-8(9)4-2/h8-9H,3-7H2,1-2H3
- Substance type: Organic
- Physical state: Colorless Liquid

Species:

rabbit

Strain:

not specified

Details on test animals or tissues and environmental conditions:

no data available

Vehicle:

not specified

Controls:

not specified

Amount / concentration applied:

0.1 ml

Duration of treatment / exposure:

72 hours

Observation period (in vivo):

21 days

Duration of post- treatment incubation (in vitro):

no data available

Number of animals or in vitro replicates:

3

Details on study design:

no data available

Irritation parameter:

overall irritation score

Basis:

mean

Time point:

21 d

Reversibility:

not specified

Remarks on result:

positive indication of irritation

Irritant / corrosive response data:

signs of irritation observed

Estimation method: Takes mode value from the 7 nearest neighbours
Domain  logical expression:Result: In Domain

(((((((((((((((((((((("a" or "b" or "c" or "d" )  and ("e" and ( not "f") )  )  and ("g" and ( not "h") )  )  and ("i" and ( not "j") )  )  and ("k" and ( not "l") )  )  and ("m" and ( not "n") )  )  and "o" )  and ("p" and ( not "q") )  )  and ("r" and ( not "s") )  )  and "t" )  and "u" )  and "v" )  and ("w" and ( not "x") )  )  and ("y" and ( not "z") )  )  and ("aa" and ( not "ab") )  )  and ("ac" and ( not "ad") )  )  and ("ae" and ( not "af") )  )  and ("ag" and ( not "ah") )  )  and "ai" )  and ("aj" and ( not "ak") )  )  and ("al" and ( not "am") )  )  and ("an" and "ao" )  )

Domain logical expression index: "a"

Referential boundary: The target chemical should be classified as Alcohol AND Hydroxy compound AND Secondary alcohol by Organic functional groups, Norbert Haider (checkmol)

Domain logical expression index: "b"

Referential boundary: The target chemical should be classified as Aliphatic Carbon [CH] AND Aliphatic Carbon [-CH2-] AND Aliphatic Carbon [-CH3] AND Hydroxy, aliphatic attach [-OH] by Organic functional groups (US EPA)

Domain logical expression index: "c"

Referential boundary: The target chemical should be classified as Alcohol by Organic Functional groups (nested)

Domain logical expression index: "d"

Referential boundary: The target chemical should be classified as Alcohol by Organic Functional groups

Domain logical expression index: "e"

Referential boundary: The target chemical should be classified as No alert found by DNA binding by OECD

Domain logical expression index: "f"

Referential boundary: The target chemical should be classified as Acylation OR Acylation >> Isocyanates and Isothiocyanates OR Acylation >> Isocyanates and Isothiocyanates >> Isocyanates OR Michael addition OR Michael addition >> P450 Mediated Activation to Quinones and Quinone-type Chemicals OR Michael addition >> P450 Mediated Activation to Quinones and Quinone-type Chemicals >> Arenes OR Michael addition >> P450 Mediated Activation to Quinones and Quinone-type Chemicals >> Hydroquinones OR Michael addition >> Polarised Alkenes-Michael addition OR Michael addition >> Polarised Alkenes-Michael addition >> Alpha, beta- unsaturated amides OR Michael addition >> Polarised Alkenes-Michael addition >> Alpha, beta- unsaturated esters OR Michael addition >> Polarised Alkenes-Michael addition >> Alpha, beta- unsaturated ketones OR Schiff base formers OR Schiff base formers >> Chemicals Activated by P450 to Glyoxal  OR Schiff base formers >> Chemicals Activated by P450 to Glyoxal  >> Ethanolamines (including morpholine) OR Schiff base formers >> Chemicals Activated by P450 to Glyoxal  >> Ethylenediamines (including piperazine) OR Schiff base formers >> Direct Acting Schiff Base Formers OR Schiff base formers >> Direct Acting Schiff Base Formers >> Mono aldehydes OR SN1 OR SN1 >> Iminium Ion Formation OR SN1 >> Iminium Ion Formation >> Aliphatic tertiary amines OR SN1 >> Nitrenium Ion formation OR SN1 >> Nitrenium Ion formation >> Aromatic azo OR SN1 >> Nitrenium Ion formation >> Aromatic nitro OR SN1 >> Nitrenium Ion formation >> Primary (unsaturated) heterocyclic amine OR SN1 >> Nitrenium Ion formation >> Primary aromatic amine OR SN1 >> Nitrenium Ion formation >> Secondary aromatic amine OR SN1 >> Nitrenium Ion formation >> Tertiary aromatic amine OR SN2 OR SN2 >> Direct Acting Epoxides and related OR SN2 >> Direct Acting Epoxides and related >> Epoxides OR SN2 >> SN2 at an sp3 Carbon atom OR SN2 >> SN2 at an sp3 Carbon atom >> Aliphatic halides OR SN2 >> SN2 at an sp3 Carbon atom >> Phosphates OR SN2 >> SN2 at an sp3 Carbon atom >> Sulfonates by DNA binding by OECD

Domain logical expression index: "g"

Referential boundary: The target chemical should be classified as No alert found by DNA binding by OASIS v.1.3

Domain logical expression index: "h"

Referential boundary: The target chemical should be classified as AN2 OR AN2 >> Carbamoylation after isocyanate formation OR AN2 >> Carbamoylation after isocyanate formation >> N-Hydroxylamines OR AN2 >> Schiff base formation by aldehyde formed after metabolic activation OR AN2 >> Schiff base formation by aldehyde formed after metabolic activation >> Geminal Polyhaloalkane Derivatives OR AN2 >> Shiff base formation for aldehydes OR AN2 >> Shiff base formation for aldehydes >> Geminal Polyhaloalkane Derivatives OR Non-covalent interaction OR Non-covalent interaction >> DNA intercalation OR Non-covalent interaction >> DNA intercalation >> DNA Intercalators with Carboxamide Side Chain OR Radical OR Radical >> Generation of reactive oxygen species OR Radical >> Generation of reactive oxygen species >> Thiols OR Radical >> Radical mechanism by ROS formation (indirect) or direct radical attack on DNA OR Radical >> Radical mechanism by ROS formation (indirect) or direct radical attack on DNA >> Organic Peroxy Compounds OR Radical >> Radical mechanism via ROS formation (indirect) OR Radical >> Radical mechanism via ROS formation (indirect) >> Geminal Polyhaloalkane Derivatives OR Radical >> Radical mechanism via ROS formation (indirect) >> N-Hydroxylamines OR SN1 OR SN1 >> Nucleophilic attack after metabolic nitrenium ion formation OR SN1 >> Nucleophilic attack after metabolic nitrenium ion formation >> N-Hydroxylamines OR SN2 OR SN2 >> Acylation involving a leaving group  OR SN2 >> Acylation involving a leaving group  >> Geminal Polyhaloalkane Derivatives OR SN2 >> Acylation involving a leaving group after metabolic activation OR SN2 >> Acylation involving a leaving group after metabolic activation >> Geminal Polyhaloalkane Derivatives OR SN2 >> DNA alkylation OR SN2 >> DNA alkylation >> Alkylphosphates, Alkylthiophosphates and Alkylphosphonates OR SN2 >> Nucleophilic substitution at sp3 carbon atom after thiol (glutathione) conjugation OR SN2 >> Nucleophilic substitution at sp3 carbon atom after thiol (glutathione) conjugation >> Geminal Polyhaloalkane Derivatives by DNA binding by OASIS v.1.3

Domain logical expression index: "i"

Referential boundary: The target chemical should be classified as Non binder, non cyclic structure by Estrogen Receptor Binding

Domain logical expression index: "j"

Referential boundary: The target chemical should be classified as Non binder, impaired OH or NH2 group OR Non binder, MW>500 OR Non binder, without OH or NH2 group OR Strong binder, OH group OR Very strong binder, OH group OR Weak binder, OH group by Estrogen Receptor Binding

Domain logical expression index: "k"

Referential boundary: The target chemical should be classified as No alert found by Protein binding by OASIS v1.3

Domain logical expression index: "l"

Referential boundary: The target chemical should be classified as Acylation OR Acylation >> Ester aminolysis OR Acylation >> Ester aminolysis >> Amides OR Nucleophilic addition OR Nucleophilic addition >> Addition to carbon-hetero double bonds OR Nucleophilic addition >> Addition to carbon-hetero double bonds >> Ketones OR SN2 OR SN2 >> SN2 Reaction at a sp3 carbon atom OR SN2 >> SN2 Reaction at a sp3 carbon atom >> Activated alkyl esters and thioesters  by Protein binding by OASIS v1.3

Domain logical expression index: "m"

Referential boundary: The target chemical should be classified as Not known precedent reproductive and developmental toxic potential by DART scheme v.1.0

Domain logical expression index: "n"

Referential boundary: The target chemical should be classified as Alkoxy propanol derivatives OR Alkyl amide, urea, thiourea, nitroso urea, carbonate, guanidine and carbamate derivatives (21b1) OR Alkyl amide, urea, thiourea, nitroso urea, carbonate, guanidine and carbamate derivatives (21b1) >> Alkylamide or thioamide analogs OR Alpha-hydroxy and alkoxyacetic acid derivatives (22b) OR Beta alkyl substituted alcohols- sub category (25b) OR C1 to C4 non-branched alkyl alcohols- sub category (25a) OR Di-substituted hydrocarbons (24a) OR Di-substituted hydrocarbons (24b) OR Di-substituted hydrocarbons (24c) OR Known precedent reproductive and developmental toxic potential OR Metal atoms were identified OR Multi-halogenated alkyl ethers (23b) OR Not covered by current version of the decision tree OR Organophosphorus compounds (1b) by DART scheme v.1.0

Domain logical expression index: "o"

Referential boundary: The target chemical should be classified as Bioavailable by Lipinski Rule Oasis ONLY

Domain logical expression index: "p"

Referential boundary: The target chemical should be classified as Non-Metals by Groups of elements

Domain logical expression index: "q"

Referential boundary: The target chemical should be classified as Alkali Earth OR Halogens OR Metals OR Transition Metals by Groups of elements

Domain logical expression index: "r"

Referential boundary: The target chemical should be classified as Group 14 - Carbon C AND Group 16 - Oxygen O by Chemical elements

Domain logical expression index: "s"

Referential boundary: The target chemical should be classified as Group 15 - Nitrogen N OR Group 16 - Sulfur S by Chemical elements

Domain logical expression index: "t"

Similarity boundary:Target: CCCCCC(O)CC
Threshold=20%,
Dice(Atom centered fragments)
Atom type; Count H attached; Hybridization

Domain logical expression index: "u"

Similarity boundary:Target: CCCCCC(O)CC
Threshold=30%,
Dice(Atom centered fragments)
Atom type; Count H attached; Hybridization

Domain logical expression index: "v"

Similarity boundary:Target: CCCCCC(O)CC
Threshold=50%,
Dice(Atom centered fragments)
Atom type; Count H attached; Hybridization

Domain logical expression index: "w"

Referential boundary: The target chemical should be classified as Inclusion rules not met by Skin irritation/corrosion Inclusion rules by BfR

Domain logical expression index: "x"

Referential boundary: The target chemical should be classified as Ethylenglycolethers by Skin irritation/corrosion Inclusion rules by BfR

Domain logical expression index: "y"

Referential boundary: The target chemical should be classified as (!Undefined)Group All Lipid Solubility < 0.01 g/kg AND (!Undefined)Group C Surface Tension > 62 mN/m by Skin irritation/corrosion Exclusion rules by BfR

Domain logical expression index: "z"

Referential boundary: The target chemical should be classified as Group C Vapour Pressure < 0.0001 Pa by Skin irritation/corrosion Exclusion rules by BfR

Domain logical expression index: "aa"

Referential boundary: The target chemical should be classified as No alert found by in vivo mutagenicity (Micronucleus) alerts by ISS

Domain logical expression index: "ab"

Referential boundary: The target chemical should be classified as H-acceptor-path3-H-acceptor by in vivo mutagenicity (Micronucleus) alerts by ISS

Domain logical expression index: "ac"

Referential boundary: The target chemical should be classified as Aliphatic monoalcohols by Eye irritation/corrosion Inclusion rules by BfR

Domain logical expression index: "ad"

Referential boundary: The target chemical should be classified as Inclusion rules not met by Eye irritation/corrosion Inclusion rules by BfR

Domain logical expression index: "ae"

Referential boundary: The target chemical should be classified as No alert found by Carcinogenicity (genotox and nongenotox) alerts by ISS

Domain logical expression index: "af"

Referential boundary: The target chemical should be classified as Structural alert for nongenotoxic carcinogenicity OR Substituted n-alkylcarboxylic acids (Nongenotox) by Carcinogenicity (genotox and nongenotox) alerts by ISS

Domain logical expression index: "ag"

Referential boundary: The target chemical should be classified as Aliphatic alcohol  [-OH] AND -CH-   [linear] AND -CH2-  [linear] AND Methyl  [-CH3] by Biodegradation fragments (BioWIN MITI)

Domain logical expression index: "ah"

Referential boundary: The target chemical should be classified as -C=CH  [alkenyl hydrogen] OR Carbon with 4 single bonds & no hydrogens by Biodegradation fragments (BioWIN MITI)

Domain logical expression index: "ai"

Referential boundary: The target chemical should be classified as Fast by Bioaccumulation - metabolism half-lives ONLY

Domain logical expression index: "aj"

Referential boundary: The target chemical should be classified as Canada DSL AND ECHA PR AND EINECS AND METI Japan AND NICNAS AND REACH ECB AND TSCA by Inventory Affiliation

Domain logical expression index: "ak"

Referential boundary: The target chemical should be classified as (N/A) by Inventory Affiliation

Domain logical expression index: "al"

Referential boundary: The target chemical should be classified as Aquatic OASIS AND ECOTOX AND Phys-chem EPISUITE by Database Affiliation

Domain logical expression index: "am"

Referential boundary: The target chemical should be classified as Aquatic Japan MoE by Database Affiliation

Domain logical expression index: "an"

Parametric boundary:The target chemical should have a value of log Kow which is >= 1.82

Domain logical expression index: "ao"

Parametric boundary:The target chemical should have a value of log Kow which is <= 3.79

Interpretation of results:

Category 2 (irritating to eyes) based on GHS criteria

Conclusions:

Octan-3-ol was estimated to be irritating to the eyes of rabbits.

Executive summary:

The ocular irritation potential of Octan-3-ol was estimated using OECD QSAR toolbox version 3.3 with logPow as the primary descriptor.

Octan-3-ol was estimated to be irritating to the eyes of rabbits.

Based on the estimated result; Octan-3-ol can be considered irritating to the eyes and can be classified under the category “Category 2” as per CLP regulation.

Endpoint conclusion

Endpoint conclusion:

adverse effect observed (irritating)

Respiratory irritation

Endpoint conclusion

Endpoint conclusion:

no study available

Additional information

Skin Irritation:

In different studies, 3-octanol has been investigated for potential for dermal irritation to a greater or lesser extent. The studies are based on in vivo experiments in rabbits, humans along with predicted data for target chemical and its structurally similar read across chemicals,2-ethylhexyl alcohol[CAS: 104-76-7] and Hexan-1-ol[CAS: 111-27-3].The predicted data using the OECD QSAR toolbox has also been compared with the experimental data.

Various studies for 3-octanol were summarized Food and Cosmetics Toxicology,Volume 17, Supplement, December 1979, Page 881; to assess the dermal irritation potential in humans and rabbits.

3-octanol applied at full strength to intact or abraded rabbit skin underocclusion was irritating after 24 hours exposure. Also, when tested on 29 human subjects at 12% in petrolatum in a 48-hr closed-patch test,3-octanol produced no irritation.

 

In a prediction done by SSS (2018) using the OECD QSAR toolbox v3.3 with log kow as the primary descriptor, the dermal irritation potential was estimated for 3 -octanol. 3-octanol was estimated to be irritating to the skin of rabbits.

The limit concentrations for skin irritation of 3-octanol was determined by G. Jacobs et.al (REGULATORY TOXICOLOGY AND PHARMACOLOGY, 7,370-378, (1987)) by testing five different dilutions ranging from undiluted (100%) to 5% in rabbits. The study was performed according to the procedures mentioned in Annexes V and VI, part IID, of Directive 79/83 l/EEC.5-6 adult Male and female New Zealand White or White of Dendermont albino rabbits were used for the study. The dorsolumbar zone was shaved 7 days before the test at both sides of the spinal column.

The limit concentrations for skin irritation of the chemical substances selected were obtained by testing five different dilutions ranging from undiluted (100%) to 5%. The highest tested concentration at which the substance is not considered an irritant to the skin according to the criteria laid out in Annex VI, part IID, of Directive 79/83 1/EEC is regarded as the limit concentration. The first concentration to be applied was selected on the basis of existing literature data.

0.5 ml dilutions of the test substances in PEG 400were applied onto the shaved skin of rabbits by means of a modified Finn chamber for 4 hours. The dilutions of the test substances used were 50, 25, 10, and 5% by weight. At the other site of the spinal column an exposure chamber containing 0.5 ml of the control vehicle was applied. The untreated skin was also used as a control. Afterward the exposure chamber was removed and the skin cleaned. Reading of erythema and edema was performed according to the scale of Draize at 1, 24, 48, and 72 hr after the removal of the patch.

The Limit dose concentration of 3-octanol was obtained at 50% w/w.

Polyethyleneglycol MW 400 when tested according to the above test procedures was determined to be not irritating to skin.

According to definition of limit dose, 3-octanol was considered to be not irritating to skin at the highest dose tested.

R. A. SCALA & E. G. BURTIS (American Industrial Hygiene Association Journal, (1973), 34:11, 493-499) performed acute dermal irritation studies on the structurally similar read across chemicals,2-ethylhexyl alcohol[CAS: 104-76-7] and Hexan-1-ol[CAS: 111-27-3]to ascertain the degree of dermal irritation caused by them.  Hexan-1-ol was applied full-strength to the closely clipped, intact abdominal skin of albino rabbits in groups of four. The exposed area was covered with an occlusive binding of dental damming for 24 hours. After the exposure, the binding was removed, and the remaining material, if any, was cleaned from the skin. The animals were housed individually with feed and water freely available. No mechanical restraints were used. Observations for dermal irritation were made on a daily basis. Gross necropsies were performed at the end of the experiments. Grading scale was slight-moderate-marked and severe.

The signs of irritation observed in the rabbits after dosing with 2-ethylhexyl alcohol[CAS: 104-76-7] and Hexan-1-ol[CAS: 111-27-3]were slight to moderate erythema, slight to moderate edema, as well as atonia, blanching, desquamation and eschar formation. These signs persisted till the termination of the study.

Based on these findings, 2-ethylhexyl alcohol[CAS: 104-76-7] and Hexan-1-ol[CAS: 111-27-3] were considered to be moderately irritating to rabbit skin.

Even though results from the human and rabbit study claim that 3-octanol was not irritating to skin, but in those studies 3-octanol was used in diluted form. Whereas results from another rabbit study indicate a possibility of 3-octanol being irritating to skin when used undiluted. Hence, it can be suggested that undiluted 3-octanol causes irritation to skin.

Hence based on the available data for the target and structure similar read chemicals, applying the weight of evidence approach,3-octanol was considered to be irritating to skin.Comparing the above annotations with the criteria of CLP regulation, test chemical can be classified under the category “Category 2”.

Eye Irritation:

In different studies,3-octanol has been investigated for potential for ocular irritation to a greater or lesser extent. The studies are based on in vivo experiments in rabbits along with predicted data for target chemical and its structurally similar read across chemicals,2-ethylhexyl alcohol[CAS: 104-76-7] and Hexan-1-ol[CAS: 111-27-3].The predicted data using the OECD QSAR toolbox has also been compared with the experimental data.

In a prediction done by SSS (2018) using the OECD QSAR toolbox v3.3 with log kow as the primary descriptor, the ocular irritation potential was estimated for 3 -octanol. 3-octanol was estimated to be irritating to the eyes of rabbits.

R. A. SCALA & E. G. BURTIS( American Industrial Hygiene Association Journal, (1973), 34:11, 493-499) performed acute eye irritation studies on the structurally similar read across chemicals,2-ethylhexyl alcohol[CAS: 104-76-7] and Hexan-1-ol[CAS: 111-27-3]to ascertain the degree of ocular irritation caused by them. A single application of 0.1 ml of undiluted alcohol was made into the conjunctival sac of the left eye of each of six rabbits. The untreated eye served as the control. The treated eye was closed for 30 seconds and eyes were not washed. Observations for irritancy and possible systemic toxicity were made at 1, 4, and 24 hours and at 2, 3, 4, and 7 days. Where positive effects persisted, observations were continued initially and at termination the eyes were examined following instillation of 2 % sodium fluorescein solution to detect any corneal lesions if not otherwise visible. Signs of irritation exposure were graded and scored according to the method of Draize.

In case of 2-ethylhexyl alcohol[CAS: 104-76-7], Persistent widespread corneal opacity was observed till 7 days in the rabbits. The median scores were 19, 20 and 0 at 24 hours, 72 hours and day 7 respectively. Hence, 2-ethylhexyl alcohol was considered to be severely irritating to rabbit eyes. Whereas Hexan-1-ol caused severe irritation involving all eye structures. Persistent iritis, corneal opacity and in two animals, corneal vascularization were observed which led to the rating of severe irritation.

Hence, Hexan-1-ol was considered to be severely irritating to rabbit eyes.

The above results are supported by the experimental study summarized in SAX (Sax's Handbook of Dangerous Industrial Materials):- Archives of Industrial Hygiene and Occupational Medicine; 1951, 4, 119; for thestructurally similar read across chemical, Hexan-1-ol[CAS: 111-27-3]. 250 g of hexan-1-ol instilled into rabbit eye and effects were observed till 72 hours and reactions were scored. The maximum score was 10. Scores over 5 were considered to cause severe eye injury. Hexan-1-ol was graded 9/10 after 72 hours.

Based on the scores, Hexan-1-ol can be considered as a severe eye irritant with a possibility to cause injury to rabbit eyes.

Based on the available data for the target as well as read across chemicals and applying the weight of evidence approach,3-octanol was irritating to eyes.Comparing the above annotations with the criteria of CLP regulation, test chemical can be classified under the category “Category 2”.

Justification for classification or non-classification

Available data for Octan-3-ol indicates that it is likely to cause irritation or corrosion to eyes and skin.

Hence, Octan-3-ol can be classified under the category “Category 2” for skin and eye irritation as per CLP regulation.