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EC number: 220-076-0 | CAS number: 2623-23-6
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 15 Jan to 20 Jan 2015
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Staatliches Gewerbeaufsichtsamt Hildeshelm
- Type of method:
- flask method
- Key result
- Water solubility:
- > 21 - < 25.4 mg/L
- Temp.:
- 20 °C
- pH:
- 6.5
- Conclusions:
- Water solubility values of 21.0 – 25.4 mg/L (at 20 °C, pH 6.5) were determined for the test substance according to E.U. Method A.6.
Reference
Results
Preliminary Test (non GLP)
The determined solubility was 18.5 mg/L, confirming the decision of the test design (flask method).
Main test
Water solubility results at 20 °C
Pre-incubation time |
Replicate No. |
Concentration1) (g/L) |
Mean |
24 h |
1 |
23.13) |
27.53) |
2 |
31.93) |
||
48 h |
1 |
22.5 |
22.7 |
2 |
22.9 |
||
72 h |
1 |
26.8 |
23.7 |
2 |
20.7 |
||
Mean (48 – 72 h) |
SD |
2.2 |
23.2 |
Deviation (%) (48 – 72)2) |
CV (%) |
9.6 |
5 |
1) Mean values of two injections
2) Calculated according to the formula
3) Not considered for calculation
SD Standard deviation
CV Coefficient of variation
Validity Criteria
The study was performed based on OECD Guideline 105 for Testing of Chemicals (1995) and Council Regulation (EC) No. 440/2008, Method A.6. The validity criteria were fulfilled:
- The concentration measured for the two longest incubation times (48 and 72 h) did not differ by more than 15 %.
- Temperatures were kept constant within ± 0.5 °C.
Conclusions
The solubility of the test item was determined to be 23.2 ± 2.2 mg/L (pH 6.5) at 20 ± 0.5 °C.
Description of key information
Water solubility: 21.0 – 25.4 mg/L at 20 °C, pH = 6.5 (EU Method A.6, flask method)
Key value for chemical safety assessment
- Water solubility:
- 23.2 mg/L
- at the temperature of:
- 20 °C
Additional information
Water solubility values of 21.0 – 25.4 mg/L (at 20 °C, pH 6.5) were determined for the test substance according to E.U. Method A.6.
As key value for chemical safety assessment the mean value of 23.2 mg/L was used.
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