Registration Dossier
Registration Dossier
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EC number: 225-555-8 | CAS number: 4926-55-0
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
The EC50 of the 2-[(2-nitrophenyl)amino]ethanol on Daphnia magna after 48 h of exposure under static conditions is 92.8 mg/L (95% confidence Interval = 70.9 - >100 mg/L) expressed as nominal concentration (measured concentrations represent more than 80% of the nominal concentrations). The 48h-EC10 is 46.7 mg/L (95% confidence Interval : 32.9 - 66.3 mg/L) and the NOEC is 20.7 mg/L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 92.8 mg/L
Additional information
The acute toxicity of the substance 2-[(2-nitrophenyl)amino]ethanol to Daphnia magna was tested according to the OECD guideline 202 and the EU method C.2, and in conformity with the GLP.
The study was conducted under static conditions. 20 daphnies were exposed during the 48h to the following nominal concentrations : 4.3 - 9.4 - 20.7 - 45.5 - 100 mg/L. Analysis by High Performance Liquid Chromatography of the tested concentrations at the start of the test and after 48 of exposure demonstrate that the measured concentrations represents more than 80% of the nominal concentrations. So the results are expressed as nominal concentrations.
The water quality parameter (pH, oxygen) measured at T0 and T48h were within the acceptable limits. No immobilisation was observed in the controls. The validity criteria of the guideline were fulfilled.
The EC50 of teh substance 2 -[(2 -nitrophenyl)amino]ethanol on Daphnia magna after 48 h of exposure is 92.8 mg/L (95% confidence interval = 70.9 - >100mg/L) expressed as nominal concentration (measured concentration more than 80% of the nominal concentration). The 48h-EC10 is 46.7 mg/L (95% confidence interval : 32.9 - 66.3 mg/L) and the NOEC is 20.7 mg/L.
This study is classified as acceptable and satisfies the guideline requirement.
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