Casoil

Skin sensitisation

Administrative data

Endpoint:

skin sensitisation, other

Remarks:

Estimated based on calculation

Type of information:

other: The assessment is performed based on the identification of the molecular structure of the substance its constituents via standard laboratory tests and evaluation of the results with associated skin sensitation potential.

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: The assessment is performed based on the identification of the molecular structure of the substance its constituents via standard laboratory tests and evaluation of the results with associated skin sensitation potential.

Justification for type of information:

The assessment is performed based on the identification of the molecular structure of the substance and its constituents via standard analytical tests and evaluation of the results with associated skin sensitation potential.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2017

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

The assessment is performed based on the identification of the molecular structure of the substance its constituents via standard laboratory tests and evaluation of the results with associated skin sensitation potential.

GLP compliance:

no

Type of study:

other: The assessment is performed based on the identification of the molecular structure of the substance its constituents via standard laboratory tests and evaluation of the results with associated skin sensitation potential.

Test material

Test material information

Constituent 1

Reference substance name:

Hydrocarbons from waste rubbers and tires, thermo-mechanical depolymerisation condensate

Molecular formula:

unknown. explained in remark.

IUPAC Name:

Hydrocarbons from waste rubbers and tires, thermo-mechanical depolymerisation condensate

Test material form:

liquid

Results and discussion

In vitro / in chemico

Results

Key result

Parameter:

other: The analytical examination of the molecular structure of the constituents in comparison with toxicological properties of the known substances reveals that the UVCB substance can be considered as skin sensitizer category 1.

Remarks:

The analytical examination of the molecular structure of the constituents in comparison with toxicological properties of the known substances reveals that the UVCB substance can be considered as skin sensitizer category 1.

Remarks on result:

other: The analytical examination of the molecular structure of the constituents in comparison with toxicological properties of the known substances reveals that the UVCB substance can be considered as skin sensitizer category 1.

Remarks:

The analytical examination of the molecular structure of the constituents in comparison with toxicological properties of the known substances reveals that the UVCB substance can be considered as skin sensitizer category 1.

Any other information on results incl. tables

The analytical examination of the molecular structure of the constituents in comparison with toxicological properties of the known substances reveals that the substance can be considered as skin sensitizer due to existence of the olefins, monocyclic olefins, and bicyclic olefins and lemonen in the substance. Those functional groups are considred to casue skin sensitation. More specifically, lemonen is known to be Skin sensitizer 1. Therefore, due to presence of lemonen and iso-lemonen, the substance is also considered as skin sensitizer. In addition, by applying CLP crieteria and constituents data from ECHA database, it shows that more than 1% of the constituents are skin sensitizer (CAS number 5989 -27 -5, 7,7%) and therefore, the intermediate substance can be classified as skin sensitizer.

Applicant's summary and conclusion

Interpretation of results:

Category 1 (skin sensitising) based on GHS criteria

Conclusions:

The analytical examination of the molecular structure of the constituents in comparison with toxicological properties of the known substances reveals that the UVCB substance can be considered as skin sensitizer category 1.

Executive summary:

The assessment is performed based on the identification of the molecular structure of the substance and its constituents via standard laboratory tests and evaluation of the results. the analysis reveals that there are functional groups such as olefins, monocyclic olefins, and bicyclic olefins and lemonen in the substance. Those finctional groups are considred to casue skin sensitation. More specifically, lemonen is known to be Skin sensitizer 1. Therefore, due to presence of lemonen and iso-lemonen, the UVCB substance is also considered as skin sensitizer.