Registration Dossier
Registration Dossier
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EC number: 249-984-5 | CAS number: 29976-53-2
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 04 September 2016 - 22 December 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7840 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- other: Preliminary test
- Remarks:
- Test item was stirred and afterwards visually evaluated.
Test material
- Reference substance name:
- Ethyl 4-oxopiperidine-1-carboxylate
- EC Number:
- 249-984-5
- EC Name:
- Ethyl 4-oxopiperidine-1-carboxylate
- Cas Number:
- 29976-53-2
- Molecular formula:
- C8H13NO3
- IUPAC Name:
- ethyl 4-oxopiperidine-1-carboxylate
- Test material form:
- liquid
- Details on test material:
- - Name of test material (as cited in study reports): JNJ-126971-AAA (T000509)
- Physical state: liquid
- Appearance: clear colourless to light yellow liquid
Constituent 1
- Specific details on test material used for the study:
- - Batch n°: M15HB3826
- Expiration date: 13 January 2017
- Analytical purity: 98.5% (based on GC purity)
- Storage condition of test material: At room temperature
Results and discussion
Water solubility
- Key result
- Water solubility:
- > 1 000 g/L
- Conc. based on:
- test mat. (dissolved fraction)
- Incubation duration:
- 5.23 h
- Temp.:
- 20 °C
- pH:
- 4.6
- Details on results:
- Preliminary test
After the stirring period, the test sample was clear and no undissolved test item was observed.
As the test item was miscible with water in a 1:1 ratio (w/v) by means of visual observation the main study was not performed.
Applicant's summary and conclusion
- Conclusions:
- A preliminary test was applied for the determination of the water solubility of JNJ-126971-AAA (T000509).
The water solubility of the test item at 20°C was >1E+3 g/L.
The pH of the aqueous sample was 4.6.
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