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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
data is from authoritative database

Data source

Referenceopen allclose all

Reference Type:
other: authoritative database
Title:
Acute dermal toxicity study of 1,3-Benzenedicarbonitrile (626-17-5) in rats
Author:
U.S. National Library of Medicine
Year:
2017
Bibliographic source:
Chemidplus Database,U.S. National Library of Medicine,2017
Reference Type:
other: authoritative database
Title:
Acute dermal toxicity study of 1,3-Benzenedicarbonitrile (626-17-5) in rats
Author:
U.S. National Library of Medicine
Year:
2017
Bibliographic source:
HSDB (Hazardous Substances Data Bank); US national Library of Medicine,2017

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
Acute dermal toxicity study of 1,3-Benzenedicarbonitrile (626-17-5) in rats
GLP compliance:
not specified
Test type:
other: no data available
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
1,3-Benzenedicarbonitrile
Cas Number:
626-17-5
Molecular formula:
C8H4N2
IUPAC Name:
1,3-Benzenedicarbonitrile
Details on test material:
- Name of test material (IUPAC name): 1,3-Benzenedicarbonitrile
- Common name: 1,3-Dicyanobenzene
- Molecular formula: C8H4N2
- Molecular weight: 128.134 g/mol
- Smiles notation: c1c(cccc1C#N)C#N
- InChl: 1S/C8H4N2/c9-5-7-2-1-3-8(4-7)6-10/h1-4H
- Substance type: Organic
Specific details on test material used for the study:
- Name of test material (as cited in study report):1,3-Dicyanobenzene
- Molecular formula :C8H4N2
- Molecular weight :128.134 g/mol
- Substance type:organic

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
No data available

Administration / exposure

Type of coverage:
other: dermal
Vehicle:
not specified
Details on dermal exposure:
No data available
Duration of exposure:
No data available
Doses:
2000 mg/kg bw
No. of animals per sex per dose:
No data available
Control animals:
not specified
Details on study design:
No data available
Statistics:
No data available

Results and discussion

Preliminary study:
No data available
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: No mortality was observed at dose 2000 mg/kg bw
Mortality:
No mortality was observed at dose 2000 mg/kg bw
Clinical signs:
other: No data available
Gross pathology:
No data available
Other findings:
No data available

Applicant's summary and conclusion

Interpretation of results:
Category 5 based on GHS criteria
Conclusions:
The LD50 value was considered to be >2000 mg/kg bw,when rabbits were treated with 1,3-Benzenedicarbonitrile (626-17-5) by dermal application.
Executive summary:

In acute dermal toxicity study,rabbits were treated with 1,3-Benzenedicarbonitrile (626-17-5) in the concentration of 2000 mg/kg bw by dermal application.No mortality was observed in treated rabbits at dose 2000 mg/kg bw.Therefore, LD50 value was considered to be >2000 mg/kg bw,when rabbits were treated with 1,3-Benzenedicarbonitrile(626-17-5)by dermal application.