Registration Dossier
Registration Dossier
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EC number: 205-840-3 | CAS number: 155-04-4
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: limited but acceptable documented study report which meets basic scientific principles
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
- Principles of method if other than guideline:
- Method: other: primary skin irritation study, 24 hours exposure; 7-d observation period
- GLP compliance:
- no
Test material
- Reference substance name:
- Zinc di(benzothiazol-2-yl) disulphide
- EC Number:
- 205-840-3
- EC Name:
- Zinc di(benzothiazol-2-yl) disulphide
- Cas Number:
- 155-04-4
- Molecular formula:
- C7H5NS2.1/2Zn
- IUPAC Name:
- zinc 1,3-benzothiazole-2-thiolate
- Details on test material:
- Bantex
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- other: intact and abraded
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Duration of treatment / exposure:
- 24 h
- Observation period:
- 7 d
- Number of animals:
- 6
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24 h, 72 h
- Score:
- 0
- Max. score:
- 8
- Reversibility:
- other: no effects
- Remarks on result:
- other: no skin irritating effects observed
Any other information on results incl. tables
No skin irritating effects observed in any of the treated animals.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information
- Executive summary:
The skin irritation potential of the test substance ZMBT was evaluated in a skin irritation study with six New Zealand Albino rabbits. The finely ground test substance (0.5 mg) moistened with water was applied under semi-occlusive dressings to clipped intact and abraded skin of 6 New Zealand albino rabbits for 24 hours. A 7 day observation period followed the test substance application. The test substance ZMBT was practically non-irritating to rabbit skin (mean irritation score intact and abraded skin 24 and 72 h average: 0).
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