Reaction mass of dodecyl acrylate and tridecyl acrylate

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2017-05-24 to 2017-

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

yes

Remarks:

See below

Qualifier:

according to guideline

Guideline:

other: OECD Guideline 123 (n-octanol/water partition coefficient; slow stirring)

Deviations:

yes

Remarks:

See below

Principles of method if other than guideline:

The water solubility of the test item Reaction mass of dodecyl acrylate and tridecyl acrylate was assessed using a protocol adapted from the flask method (OECD 105) with slow stirring conditions described in the OECD test guideline 123.
Due to the viscous property of the test item, the definitive protocol was adapted from the flask method with slow stirring conditions described in the OECD 123 guideline: test solutions were prepared at a high loading rate of 1 g/L.

GLP compliance:

yes (incl. QA statement)

Type of method:

flask method

Key result

Water solubility:

16.3 µg/L

Conc. based on:

test mat.

Temp.:

20.2 °C

pH:

>= 5.7 - <= 5.9

Preliminary Test

Increasing volumes of ultra-pure water up to 100 mL were added at room temperature to approximately 0.1 g of the sample in a 100 mL glass flask. After each addition of medium, the test solution was unclear and droplets were observed (probably due to the viscous property of the test item):the approximate solubility was thus estimated to be < 1 g/L.

Definitive Test

Based on OECD test guideline 105 specifications, the saturation equilibrium was considered to be reached from time point 71.5h onwards. Indeed, the concentrations measured at the two last sampling times (76.5h and 167.5h) did not differ by more than 15% from the concentrations measured at 71.5h (see table below). The water solubility of the test item was therefore calculated as the mean of the concentrations determined during this period. The value obtained was 16.3 µg/L.

Time point (hours)	Flask	Mean	Mean of replicates	Difference from previous time point (%)	Overall Mean Measured Test Item (µg/L)
4.5	Replicate 1	NA	NA
	Replicate 2	NA
23.5	Replicate 1	15.5	15.5	NA
	Replicate 2	15.4
28.5	Replicate 1	16.1	15.5	0.3
	Replicate 2	14.9
47.5	Replicate 1	19.4	18.6	20.1
	Replicate 2	17.8
52.5	Replicate 1	20.2	19.3	3.8
	Replicate 2	18.5
71.5	Replicate 1	17.1	15.9	-18.0	16.3
	Replicate 2	14.6
76.5	Replicate 1	18.4	16.3	2.5
	Replicate 2	14.1
167.5	Replicate 1	16.6	16.9	3.9
	Replicate 2	17.1

Temperature was monitored during the test and remained between 20.2°C and 20.3°C (mean 20.2).

pH values were between pH 5.7 and 5.9 in all samples.

Conclusions:

The water solubility of the test item Reaction mass of dodecyl acrylate and tridecyl acrylate was assessed using a protocol adapted from the flask method (OECD 105) with slow stirring conditions described in the OECD test guideline 123. The water solubility of Reaction mass of dodecyl acrylate and tridecyl acrylate is 16.3 µg/L.

The test was run at 20.2°C on average (min. 20.2°C, max. 20.3°C). pH values were between 5.7 and 5.9.

Executive summary:

The water solubility of the test item Reaction mass of dodecyl acrylate and tridecyl acrylate was assessed using a protocol adapted from the flask method (OECD 105) with slow stirring conditions described in the OECD test guideline 123.

 

Due to the viscous property of the test item, the definitive protocol was adapted from the flask method with slow stirring conditions described in the OECD 123 guideline: test solutions were prepared at a high loading rate of 1 g/L.

 

Results are summarized below (all results are in µg/L):

 

Time point (hours)	Flask	Mean	Mean of replicates	Difference from previous time point (%)	Overall Mean Measured Test Item
4.5	Replicate 1	NA	NA
	Replicate 2	NA
23.5	Replicate 1	15.5	15.5	NA
	Replicate 2	15.4
28.5	Replicate 1	16.1	15.5	0.3
	Replicate 2	14.9
47.5	Replicate 1	19.4	18.6	20.1
	Replicate 2	17.8
52.5	Replicate 1	20.2	19.3	3.8
	Replicate 2	18.5
71.5	Replicate 1	17.1	15.9	-18.0	16.3
	Replicate 2	14.6
76.5	Replicate 1	18.4	16.3	2.5
	Replicate 2	14.1
167.5	Replicate 1	16.6	16.9	3.9
	Replicate 2	17.1

 

The solubility of Reaction mass of dodecyl acrylate and tridecyl acrylate is 16.3 µg/L.

 

The test was run at 20.2°C on average (min. 20.2°C, max. 20.3°C). pH values were between pH 5.7 and 5.9.

 

Description of key information

The water solubility of the test item Reaction mass of dodecyl acrylate and tridecyl acrylate was determined by an experimental study adapted from the flask method (OECD Test Guideline 105) with slow-stirring conditions described in the OECD Test Guideline 123.

The solubility of Reaction mass of dodecyl acrylate and tridecyl acrylate is 16.3 µg/L at 20.2°C (pH between 5.7 and 5.9).

Key value for chemical safety assessment

Water solubility:

16.3 µg/L

at the temperature of:

20.2 °C