Registration Dossier
Registration Dossier
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EC number: 298-078-6 | CAS number: 93777-46-9
Endpoint summary
Administrative data
Description of key information
Additional information
Reliable ecotoxicological data are available for Decyl 2-ethylhexanoate (CAS 93777-46-9) for long-term toxicity toaquatic invertebrates and toxicity to algae. There are no ecotoxicological data available for short-term toxicity to fish. Therefore, read-across to the two structurally related substances Fatty acids, C8-16, 2-ethylhexyl esters (CAS 135800-37-2) and Hexanoic acid, 2-ethyl-, C16-18 alkyl esters (CAS 90411-68-0) was conducted in order to fulfil the standard information requirements in compliance with Annex XI, 1.5, of Regulation (EC) No 1907/2006. Based on the high degree of similarity between the structural and physico-chemical properties of the target and source substances, the source substances are considered suitable representatives for the assessment of the short-term toxicity to fish of the target substance. A detailed analogue approach justification is provided in the technical dossier (see IUCLID Section 13).
All experimental studies available for the target and the source substances were performed according to internationally accepted guidelines. They cover all three trophic levels of an aquatic ecosystem. Toxicity was observed below 1 mg/L, but above the water solubility (1.82 - 2.40 µg/L at 20 °C) of the target substance. Thus, observed toxicity was not considered to be relevant in an aquatic ecosystem.
The short-term toxicity to fish was determined in studies according to OECD guideline 203 and EU Method C.1 for the source substances Fatty acids, C8-16, 2-ethylhexyl esters (CAS 135800-37-2) and Hexanoic acid, 2-ethyl-, C16-18 alkyl esters (CAS 90411-68-0). No effects were observed in both tests.
One non-reliable experimental study is available investigating the short-term toxicity of the target substance Decyl 2-ethylhexanoate (CAS 93777-46-9) to Daphnia magna according to OECD guideline 202. The EC50 (48 h) was determined to be at 17.5 mg/L (nominal). But this study has to be treated with caution as only limited information are available and the calculation of the effect value is not conclusive. In addition, no analytical measurements were performed. Since the target substance has a low water solubility (1.82 - 2.40 µg/L), evaluation of the test results without analytical measurements is not possible.
The chronic toxicity of the target substance Decyl 2-ethylhexanoate (CAS 93777-46-9) to Daphnia magna was tested in a semi-static study according to OECD 211 (GLP). An EC10 (21 d) of > 2.8 µg/L was determined, which is above the water solubility of the target substance.
The toxicity to aquatic algae was tested in a study according to OECD 201 (GLP) for the target substance Decyl 2-ethylhexanoate (CAS 93777-46-9) and resulted in an ErC50 (72 h) of > 0.13 mg/L (TWA) and the NOErC (72 h) of 0.13 mg/L (TWA) based on inhibition of growth.
The toxicity to microorganisms was assessed using the toxicity control of the biodegradation test (OECD 301B) for Decyl 2-ethylhexanoate (CAS 93777-46-9). The toxicity control attained 38% degradation after 14 days of incubation. Hence, the substance is not toxic to aquatic microorganisms in the toxicity control and a NOEC (14 d) of ≥ 16 mg/L was derived.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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