Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
dermal absorption
Type of information:
(Q)SAR
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
Model is based on accepted principles of skin permeation and diffusion of chemicals through a semi-permeable membrane. It was validated with an extensive database of experimentally measured permeation coefficients and is considered valid for substances with log Kow values in the range from 0 to 4.
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6

Data source

Reference
Reference Type:
other: QSAR model
Title:
Skinperm version 3.0
Author:
ten Berge W
Year:
2015
Bibliographic source:
http://home.planet.nl/~wtberge/

Materials and methods

Test material

Constituent 1
Chemical structure
Reference substance name:
2-ethoxy-1-methylethyl acetate
EC Number:
259-370-9
EC Name:
2-ethoxy-1-methylethyl acetate
Cas Number:
54839-24-6
Molecular formula:
C7H14O3
IUPAC Name:
2-ethoxy-1-methylethyl acetate
Constituent 2
Reference substance name:
259-770-9
IUPAC Name:
259-770-9

Test animals

Species:
human

Results and discussion

Percutaneous absorption
Remarks on result:
other:

Any other information on results incl. tables

The model estimates the permeation rate for ethoxypropyl acetate liquid to be 0.0497 mg/cm2/hr. For comparison purposes, the model estimates the permeation rate for methoxypropyl acetate to be 0.0505mg/cm3/hr and for the parent glycol ethers ethoxypropanol and methoxypropanol to be 0.223 and 0.169mg/cm2/hr respectively. This indicates that the parent ethers can absorb significantly more rapidly than the esters, by a factor of 3 -4 and that the length of the alkyl chain, at least methyl compared to ethyl has little effect on skin absorption.

Applicant's summary and conclusion

Executive summary:

A QSAR model predicts that the permeation rate of ethoxypropyl acetate will be 0.050mg/cm2/hr based on the physicochemical properties of the substance. The model predicts that the absorption is a factor of 3 -4x lower than that of the parent glycol ether.