Registration Dossier
Registration Dossier
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EC number: 236-412-4 | CAS number: 13360-57-1
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1977
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Test procedure in accordance with national standard methods with acceptable restrictions.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Dimethylsulphamoyl chloride
- EC Number:
- 236-412-4
- EC Name:
- Dimethylsulphamoyl chloride
- Cas Number:
- 13360-57-1
- Molecular formula:
- C2H6ClNO2S
- IUPAC Name:
- N,N-dimethylsulfamoyl chloride
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Breeder Winkelmann, Borchen, Kreis Paderborn
- Age at study initiation: no data
- Weight at study initiation: 160 - 240 g
- Fasting period before study: 16 hours
- Housing: Makrolone cage
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: no data
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- 24 hours
- Doses:
- males: 500 / 750 / 1000 / 1750 / 2500 / 5000 mg/kg bw ;
females: 100 / 250 / 350 / 500 / 750 / 1000 / 1500 mg/kg bw - No. of animals per sex per dose:
- male: 10 animals; female: 10 animals
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 620 mg/kg bw
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 527 mg/kg bw
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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