Sodium 3-(p-anilinophenylazo)benzenesulphonate

Density

Link to relevant study record(s)

Reference

Endpoint:

density

Remarks:

density

Type of information:

experimental study

Adequacy of study:

key study

Study period:

08-08-2017 – 08-08-2017

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Justification for type of information:

Experimental test result performed using standard test guidelines

Qualifier:

according to guideline

Guideline:

OECD Guideline 109 (Density of Liquids and Solids)

Principles of method if other than guideline:

Pour density and tapped density of powders” recommended in The International Pharmacopoeia, Fourth Edition, 2014.
Pour Density: It is the ratio of known weight of test item and its volume in graduated glass cylinder.
Tap Density: It is the difference between the volume of test item measured before & after tapping in the graduated glass cylinder.

GLP compliance:

no

Type of method:

pycnometer method

Specific details on test material used for the study:

- Name of test material : sodium 3-[(4-anilinophenyl)diazenyl]benzenesulfonate
- Molecular formula : C18H14N3O3S.Na
- Molecular weight: 375.383 g/mol
- Smiles notation : c1(Nc2ccccc2)ccc(\N=N\c2cc(ccc2)S(=O)(=O)[O-])cc1.[Na+]
- InChl : 1S/C18H15N3O3S.Na/c22-25(23,24)18-8-4-7-17(13-18)21-20-16-11-9-15(10-12-16)19-14-5-2-1-3-6-14;/h1-13,19H,(H,22,23,24);/q;+1/p-1/b21-20+;
- Substance type: Organic
- Physical state: Solid

Key result

Type:

pour density

Density:

0.488 g/cm³

Temp.:

25 °C

Remarks on result:

other: Pressure: 967.2 hPa

Key result

Type:

tap density

Density:

0.646 g/cm³

Temp.:

25 °C

Remarks on result:

other: Pressure: 967.2 hPa

CALCULATIONS:

Parameters	Details	Calculated values		Average Density
		1st Calculation	2nd Calculation
Pour Density of test Item (g/cm³)	=m   V	0.5001	0.4763	0.4882
Tap density of test Item (g/cm³)	=m   V1	0.6669	0.6251	0.6460

Conclusions:

The density of test item Sodium 3-(p-anilinophenylazo)benzenesulphonate (CAS No. 587-98-4) was determined following OECD Guideline 109 and according to the Test methods: Pour density and tapped density of powders” recommended in The International Pharmacopoeia, Fourth Edition, 2014 using bulk density apparatus.The mean pour density and tapped density of test item was found to be 0.4882 g/cm³ and 0.6460 g/cm³at 25 °C and 967.2 hPa.

Executive summary:

The density of Test item Sodium 3-(panilinophenylazo) benzenesulphonate (CAS No. 587-98-4 ) was determined following OECD guideline 109 and according to the method recommended in the International Pharmacopoeia, fourth Edition, 2014. The mean pour density and tapped density of the test item was found to

be 0.4882 g/cm³ and 0.6460 g/cm³at 25 °C and 967.2 hPa.

Description of key information

The density of test item Sodium 3-(p-anilinophenylazo)benzenesulphonate (CAS No. 587-98-4) was determined following OECD Guideline 109 and according to the Test methods: Pour density and tapped density of powders” recommended in The International Pharmacopoeia, Fourth Edition, 2014 using bulk density apparatus.The mean pour density and tapped density of test item was found to be 0.4882 g/cm³ and 0.6460 g/cm³at 25 °C and 967.2 hPa.

Key value for chemical safety assessment

Relative density at 20C:

0.488

Additional information

The density of test item Sodium 3-(p-anilinophenylazo)benzenesulphonate (CAS No. 587-98-4) was determined following OECD Guideline 109 and according to the Test methods: Pour density and tapped density of powders” recommended in The International Pharmacopoeia, Fourth Edition, 2014 using bulk density apparatus.The mean pour density and tapped density of test item was found to be 0.4882 g/cm³ and 0.6460 g/cm³at 25 °C and 967.2 hPa.

Other supporting data based on prediction done using ACD/I-Lab 2.0, indicates the density of chemical sodium 3-[(4-anilinophenyl)diazenyl]benzenesulfonate to be 1.41 ± 0.01 g/cm3.