Registration Dossier
Registration Dossier
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EC number: 257-827-7 | CAS number: 52301-70-9
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1974
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- other: Method B-10 (Method used at Ciba Geigy).
- Deviations:
- not specified
- GLP compliance:
- no
- Analytical monitoring:
- no
- Details on sampling:
- No data
- Vehicle:
- not specified
- Details on test solutions:
- No data
- Test organisms (species):
- activated sludge
- Details on inoculum:
- None
- Test type:
- not specified
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 12 h
- Remarks on exposure duration:
- exposure duration 12-24 hours
- Post exposure observation period:
- Not applicable.
- Hardness:
- No data
- Test temperature:
- None
- pH:
- No data
- Dissolved oxygen:
- Not applicable
- Salinity:
- Not applicable
- Nominal and measured concentrations:
- None
- Details on test conditions:
- No data
- Reference substance (positive control):
- no
- Key result
- Duration:
- 12 h
- Dose descriptor:
- other: KST
- Effect conc.:
- > 300 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth inhibition
- Remarks on result:
- other: exposure duration 12-24 hours
- Details on results:
- None
- Results with reference substance (positive control):
- Not applicable
- Reported statistics and error estimates:
- None
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The KST for the substance was found to be greater than 300 mg/L.
- Executive summary:
The toxicity to acivated sludge for the substance was found to be greater than 300 mg/L.
Reference
Description of key information
In a study carried out to determine toxicity to activated sludge of the test substance, the IC50 was found to be >300 mg/L after 12 hours of exposure. Similarly, in another supporting study, the IC50 to activated sludge was again >300 mg/l. Growth inhibition was the basis for effect in both studies.
Key value for chemical safety assessment
- EC50 for microorganisms:
- 300 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
