Registration Dossier
Registration Dossier
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EC number: 271-114-8 | CAS number: 68515-88-8
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- data is from RTECS
Data source
Reference
- Reference Type:
- secondary source
- Title:
- RTECS - SB2733650
- Author:
- RTECS
- Year:
- 2 009
- Bibliographic source:
- RTECS - SB2733650,Last updated- 2009
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- To assess the dermal irritation potential of Pentene, 2,4,4-trimethyl-, sulfurized
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Pentene, 2,4,4-trimethyl-, sulfurized
- EC Number:
- 271-114-8
- EC Name:
- Pentene, 2,4,4-trimethyl-, sulfurized
- Cas Number:
- 68515-88-8
- Molecular formula:
- C24H50S8
- IUPAC Name:
- 1-(2,4,4-trimethyl-1-{[(2,4,4-trimethylpentan-2-yl)disulfanyl]disulfanyl}pentan-2-yl)-4-(2,4,4-trimethylpentan-2-yl)tetrasulfane
- Test material form:
- liquid: viscous
- Details on test material:
- - Name of test material (as cited in study report): Pentene, 2,4,4-trimethyl-, sulfurized
- Molecular formula :C24H50S8
- Molecular weight: 595.144 g/mol
- Substance type:Organic
- Physical state:Liquid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Pentene, 2,4,4-trimethyl-, sulfurized
- Molecular formula : C24H50S8
- Molecular weight: 595.144 g/mol
- SMILES: CC(C)(C)CC(C)(C)SSSSCC(C)(CC(C)(C)C)SSSSC(C)(C)CC(C)(C)C
- Substance type: Organic
- Physical state: Liquid
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- no data available
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 500 microliter
- Duration of treatment / exposure:
- 24h
- Observation period:
- 24h
- Number of animals:
- no data available
- Details on study design:
- no data available
Results and discussion
In vitro
- Other effects / acceptance of results:
- no data available
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 24 h
- Reversibility:
- not specified
- Remarks on result:
- probability of moderate irritation
- Irritant / corrosive response data:
- Moderately irritating to skin
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritant) based on GHS criteria
- Conclusions:
- Pentene, 2,4,4-trimethyl-, sulfurized was moderately irritating to rabbit skin.
- Executive summary:
A dermal irritation study was performed to assess the irritation potential of Pentene, 2,4,4-trimethyl-, sulfurized.
500 microliters of Pentene, 2,4,4-trimethyl-, sulfurized was applied to the rabbit skin and effects were observed for 24 hours.
Pentene, 2,4,4-trimethyl-, sulfurized was moderately irritating to rabbit skin.
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