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EC number: 238-877-9 | CAS number: 14807-96-6
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because the substance is highly insoluble in water, hence indicating that aquatic toxicity is unlikely to occur
- other:
- Endpoint:
- short-term toxicity to fish
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- QSAR prediction: US EPA accepted QSAR method for chemicals properties assessment.
- Qualifier:
- according to guideline
- Guideline:
- other: QSAR
- Principles of method if other than guideline:
- EPI Suite v 4.1/ECOSARv1.00
- GLP compliance:
- no
- Remarks:
- not applicable to QSAR models
- Analytical monitoring:
- not specified
- Vehicle:
- not specified
- Test organisms (species):
- other: Fishes species
- Details on test organisms:
- no further information
- Test type:
- other: QSAR model
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Hardness:
- not applicable. QSAR model
- Test temperature:
- not applicable. QSAR model
- pH:
- not applicable. QSAR model
- Dissolved oxygen:
- not applicable. QSAR model
- Salinity:
- not applicable. QSAR model
- Details on test conditions:
- Chem Name : Talc (Mg3H2(SiO3)4)
Molecular Wt: 379.27
Henry's LC : 5.54e-029 atm-m3/mole (calc VP/Wsol)
Vapor Press : 1.11e-022 mm Hg (Mpbpwin program)
Liquid VP : 1.15e-019 mm Hg (super-cooled)
Melting Pt : 330 deg C (Mpbpwin program)
Log Kow : -9.4 (Kowwin program)
Soil Koc : 31.82 (KOCWIN MCI method) - Reference substance (positive control):
- no
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 89 581.016 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: (Q)SAR prediction
- Remarks on result:
- other: non-toxic as determined by (Q)SAR
- Details on results:
- A 96 h LC50 value of 89581.016 mg/L has been calculated for the effects of the test substance on the mortality of the fish taxonomic group. This result signifies that the test substance is not expected to be toxic .
- Results with reference substance (positive control):
- A 96 h LC50 value of 89581.016 mg/L has been calculated for the effects of the test substance on the mortality of the fish taxonomic group. This result signifies that the test substance is not expected to be toxic .
- Validity criteria fulfilled:
- yes
- Remarks:
- US EPA accepted QSAR method for chemicals properties assessment.
- Conclusions:
- A 96 h LC50 value of 89581.016 mg/L has been calculated for the effects of the test substance on the mortality of the fish taxonomic group. This result signifies that the test substance is not expected to be toxic .
- Executive summary:
The ECOSAR QSAR model predicts that the 96hr LC50 for freshwater fish would to be 89581.016 mg/l .This result signifies that the test substance is not expected to be toxic.
- Endpoint:
- short-term toxicity to fish
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- QSAR prediction: US EPA accepted QSAR method for chemicals properties assessment.
- Qualifier:
- according to guideline
- Guideline:
- other: QSAR
- Principles of method if other than guideline:
- EPI Suite v 4.1/ECOSARv1.00
- GLP compliance:
- no
- Remarks:
- not applicable to QSAR models
- Analytical monitoring:
- not specified
- Vehicle:
- not specified
- Test organisms (species):
- other: Fishes species
- Details on test organisms:
- no further information
- Test type:
- other: QSAR model
- Water media type:
- saltwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Hardness:
- not applicable. QSAR model
- Test temperature:
- not applicable. QSAR model
- pH:
- not applicable. QSAR model
- Dissolved oxygen:
- not applicable. QSAR model
- Salinity:
- not applicable. QSAR model
- Details on test conditions:
- Chem Name : Talc (Mg3H2(SiO3)4)
Molecular Wt: 379.27
Henry's LC : 5.54e-029 atm-m3/mole (calc VP/Wsol)
Vapor Press : 1.11e-022 mm Hg (Mpbpwin program)
Liquid VP : 1.15e-019 mm Hg (super-cooled)
Melting Pt : 330 deg C (Mpbpwin program)
Log Kow : -9.4 (Kowwin program)
Soil Koc : 31.82 (KOCWIN MCI method) - Reference substance (positive control):
- no
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 110 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: (Q)SAR prediction
- Remarks on result:
- other: non-toxic as determined by (Q)SAR
- Details on results:
- A 96 h LC50 value of 110000 mg/L has been calculated for the effects of the test substance on the mortality of the fish taxonomic group. This result signifies that the test substance is not expected to be toxic .
- Results with reference substance (positive control):
- A 96 h LC50 value of 110000 mg/L has been calculated for the effects of the test substance on the mortality of the marine fish taxonomic group. This result signifies that the test substance is not expected to be toxic .
- Validity criteria fulfilled:
- yes
- Remarks:
- US EPA accepted QSAR method for chemicals properties assessment.
- Conclusions:
- A 96 h LC50 value of 110000 mg/L has been calculated for the effects of the test substance on the mortality of the marine fish taxonomic group. This result signifies that the test substance is not expected to be toxic .
- Executive summary:
The ECOSAR QSAR model predicts that the 96hr LC50 for marine fish would to be 110000 mg/l .This result signifies that the test substance is not expected to be toxic.
Referenceopen allclose all
Description of key information
The substance is almost insoluble in aqueous solution and Talc (Mg3H2(SiO3)4) is not expected to be harmful to aquatic life. Published studies by the European Chemicals Bureau; IUCLID Dataset, Talc (14807-96-6), 2004 show that there is no acute toxicity associated with Talc for fish. Semistatic LC50 Brachydanio rerio (Zebra fish) >100000 mg/L/24 hr; for Talc. On this basis, the need for further testing for this end point has been waived and being unnecessary and scientifically unjustified. Therefore testing for Short-term toxicity to fish does not need to be performed.
The ECOSAR QSAR model predicts that the 96hr LC50 for freshwater fish would to be 89581.016 mg/l .This result signifies that the test substance is not expected to be toxic.
The ECOSAR QSAR model predicts that the 96hr LC50 for marine fish would to be 110000 mg/l .This result signifies that the test substance is not expected to be toxic.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 89 581.016 mg/L
Marine water fish
Marine water fish
- Effect concentration:
- 110 000 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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