Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reason / purpose for cross-reference:
- read-across source
- Key result
- Duration:
- 72 h
- Dose descriptor:
- EL50
- Effect conc.:
- 46.5 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Remarks on result:
- other: 95% confidence limits: 28-89 mg/L; results are expressed in terms of loading rates
- Duration:
- 72 h
- Dose descriptor:
- EL10
- Effect conc.:
- 0.85 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Remarks on result:
- other: 95% confidence limits: 0.2-2.5 mg/L; results are expressed in terms of loading rates
- Duration:
- 72 h
- Dose descriptor:
- NOELR
- Effect conc.:
- 1 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Remarks on result:
- other: results are expressed in terms of loading rates
- Duration:
- 72 h
- Dose descriptor:
- EL50
- Effect conc.:
- 4.9 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: yield
- Remarks on result:
- other: 95% confidence limits: 4.1-5.9 mg/L; results are expressed in terms of loading rates
- Duration:
- 72 h
- Dose descriptor:
- EL10
- Effect conc.:
- 2 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: yield
- Remarks on result:
- other: 95% confidence limits: 1.1-2.8 mg/L; results are expressed in terms of loading rates
- Duration:
- 72 h
- Dose descriptor:
- NOELR
- Effect conc.:
- 0.32 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: yield
- Remarks on result:
- other: results are expressed in terms of loading rates
Reference
Description of key information
effect values for average specific growth rates of Pseudokirchneriella subcapitata, 0-72 h, based on loading rates (OECD 201, EU C.3):
EL50: 46.5 mg/L, NOELR: 1.0 mg/L, EL10: 0.85 mg/L
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 46.5 mg/L
- EC10 or NOEC for freshwater algae:
- 0.85 mg/L
Additional information
The results obtained for the read-across source substance WS405777 indicate that the test material is not inhibitory to growth of algae up to the limits of its water solubility (<1 mg/L) and a NOEC and thus a PNEC cannot be determined.
The same conclusion can be drawn for the read-across target substance WS406663 based on the close chemical similarity between the two substances (see IUCLID Section 13 „Validity Assessment Report“ for the read-across approach).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
