Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 916-737-4 | CAS number: -
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
A skin sensitisation study with Glycolierral was performed according to an open epicutaneous test method. 21 consecutive days 3, 10, 30 and 100% test material was given to 8 animals for each concentration. The highest non irritant concentration after a single and after repeated applications was 3%. Higher concentrations caused very slight to slight irritation only.
No reactions were observed at the day 21 and 35 challenge in any of the test control group animals at any of the tested concentrations.
Based on these results Glycolierral is not regarded as a skin sensitizer.
Under the conditions of a repeated insult (occlusive) patch test procedure, the test substance 5% Sample D in DMP did not induce irritation nor show any evidence of induced allergic contact dermatitis in human subjects.
Migrated from Short description of key information:
A skin sensitisation study with Glycolierral was performed according to an open epicutaneous test method and a repeated insult (occlusive) patch test was performed.
Justification for selection of skin sensitisation endpoint:
Both studies showed no evidence of skin sensitisation.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Based on the results, Glycolierral does not have to be classified for skin sensitisation according to Regulation (EC) No 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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