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EC number: 247-825-4 | CAS number: 26586-02-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1982-04-16 through 1982-07-20
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Principles of method if other than guideline:
- BASF Test (internal standard method). In principle, the methods described by OECD TG 403 were used.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- (E)-3-formylbut-2-enyl acetate
- EC Number:
- 247-825-4
- EC Name:
- (E)-3-formylbut-2-enyl acetate
- Cas Number:
- 26586-02-7
- Molecular formula:
- C7H10O3
- IUPAC Name:
- (2E)-3-methyl-4-oxobut-2-en-1-yl acetate
- Details on test material:
- - Name of test material (as cited in study report): C5-Acetat (2-methyl-4-acetoxybut-2-en-1-ol-1-al; ca. 98% trans, 2% cis)
- Physical state: liquid; colourless to slightly yellow
- Analytical purity: 98-99%
- Impurities (identity and concentrations): no data
No further data.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
male and female Wistar rats (SPF/CHbb:Thom)
- Source: Dr. K. Thomae GmbH, Biberach, Germany
- Age at study initiation: 8 weeks
- Weight at study initiation: mean weights: 226 +/- 42 g (males); 170 +/- 17 g (females)
- Fasting period before study: no data
- Housing: 5 per cage, mesh wire cages (type DIII, Becker)
- Diet (ad libitum): SSNIFF R 10 Pellet, Ssniff-Versuchstierdiäten GmbH, Soest, Germany
- Water (ad libitum): tap water
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS
- Photoperiod (hrs dark / hrs light): 12/12
No further data
IN-LIFE DATES: no data
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- nose/head only
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: Head-nose-inhalation system INA 20 (BASF AG)
- Exposure chamber volume: ca. 55 l
- Method of holding animals in test chamber: animals are placed in glass tubes with their snouts projected into the inhalation chamber
- System of generating particulates/aerosols: infusion pumps UNITA I (Braun) and UNFU 362 (INDIGEL, Switzerland) and Two-compound nozzle 970 (Schlick). A constant amount of the test substance was conducted to the nozzle; the liquid aerosol was generated using pressed air (1.2 bars) and the aerosol was conducted to the inhalation system.
- Method of particle size determination: Particle size analysis was performed with an Andersen Stack Sampler Mark III. Samples of the inhalation mixture were collected by an impactor; the content of the impactor was analyzed by gas chromatography.
TEST ATMOSPHERE
- Brief description of analytical method used: quantitative determination of the aerosol concentrations was made by gas chromatography (GC HP 5840 A, Hewlett Packard)
- Samples taken from breathing zone: yes
TEST ATMOSPHERE (if not tabulated)
- Particle size distribution: 93% of the aerosol particles are able to reach alveolar tissue after inhalation.
- MMAD (Mass median aerodynamic diameter) / GSD (Geometric st. dev.): 2.2 µm / 2.8 - Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- nominal concentrations: 1.68, 8.4, 9.1, 18.9 mg/l
analytically determined concentrations (mean +/- SD): 0.64 +/- 0.14, 2.8+/- 0.32, 4.0 +/- 0.11, 4.9 +/- 0.28 mg/l - No. of animals per sex per dose:
- 10 males and 10 females per dose group
12 animals in the control group - Control animals:
- other: a control group of 12 rats was exposed to air.
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Animals were weighed prior to exposure, after 7 days and at the end of the observation period. Clinical observations were monitored on working days. Lethality was monitored daily.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, gross pathology - Statistics:
- Statistical evaluation was made in accordance with the Probit analysis by Finney [Finney DJ (1971). Probitanalysis 1971, pp. 1-150. Published by the Syndics of the Cambridge University Press, Bentley House, 200 Euston Road, London N.W. 1].
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- 3.6 mg/L air (analytical)
- 95% CL:
- 3.1 - 4.1
- Exp. duration:
- 4 h
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- 3.57 mg/L air (analytical)
- 95% CL:
- 3 - 4.1
- Exp. duration:
- 4 h
- Sex:
- female
- Dose descriptor:
- LC50
- Effect level:
- 3.63 mg/L air (analytical)
- 95% CL:
- 1.9 - 5.1
- Exp. duration:
- 4 h
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- 14 mg/L air
- Exp. duration:
- 1 h
- Remarks on result:
- other: calculated
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- 14 mg/L air
- Exp. duration:
- 1 h
- Remarks on result:
- other: calculated
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- 15 mg/L air
- Exp. duration:
- 1 h
- Remarks on result:
- other: calculated
- Mortality:
- Mortality rates:
group 1: 10/10 males; 8/10 females
group 2: 5/10 males; 5/10 females
group 3: 2/10 males; 3/10 females
group 4: 0/10 males; 0/10 females
All deaths occurred within 2 days after exposure.
For details, see table below. - Clinical signs:
- other: Groups 1, 2 and 3: restlessness, eyelid closure, serous ocular and nasal secretion, salivation, redness of the ears and extremities during exposure; reddish encrustation of the nose, slight serous nasal secretion, prone position, squatting posture after
- Body weight:
- Body weight gain was significantly retarded in group-2 males during the first week of post-observation. Males of groups 3 and 4 showed slight retardation of body weight gains during this period. Body weight gains of all females showed only slight alterations during post-observation week 1.
- Gross pathology:
- Findings in decedents (males and females):
Group 1: multiple secretory smears at the fur of the abdomen, snout, extremities and testes and sporadically centroacinar fatty degeneration of the hepatocytes.
Group 2: pulmonary emphysema, multiple pulmonary edemas, sporadically gaseous content of the stomach and intestine, spotted clay-like discoloration of the liver.
Group 3: pulmonary edema, sporadical lung emphysema, sporadical clay-like discoloration of the liver, acute dystrophy, fatty necrosis.
No abnormalities were observed in survivors sacrificed at the end of the study.
Any other information on results incl. tables
Table 2:Mortality data
Lethality time |
Group |
|||||||
1 (4.9 mg/l) |
2 (4.0 mg/l) |
3 (2.8 mg/l) |
4 0.64 mg/l) |
|||||
no. of dead animals / no. of exposed animals |
||||||||
m |
f |
m |
f |
m |
f |
m |
f |
|
4 h |
8/10 |
5/10 |
2/10 |
2/10 |
0/10 |
0/10 |
0/10 |
0/10 |
1 d |
9/10 |
6/10 |
4/10 |
3/10 |
2/10 |
2/10 |
- |
- |
2 d |
10/10 |
8/10 |
5/10 |
5/10 |
- |
3/10 |
- |
- |
7 d |
- |
- |
- |
- |
- |
- |
- |
- |
14 d |
- |
- |
- |
- |
- |
- |
- |
- |
total mortality |
18/20 |
10/20 |
5/20 |
0/20 |
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Remarks:
- Migrated information
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