Trisodium 8-hydroxypyrene-1,3,6-trisulphonate

Hydrolysis

Link to relevant study record(s)

Reference

Endpoint:

hydrolysis

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Remarks:

experimental data of read across substances

Justification for type of information:

Data for the target chemical is summarized based on the structurally similar read across chemicals

Reason / purpose for cross-reference:

read-across source

Reason / purpose for cross-reference:

read-across source

Qualifier:

according to guideline

Guideline:

other: as mentioned below

Principles of method if other than guideline:

WoE report is based on two hydrolysis studies as-
2. and 3.

GLP compliance:

not specified

Radiolabelling:

yes

Remarks:

2. yes and 3. Not specified

Analytical monitoring:

yes

Remarks:

2. yes and 3. Not specified

Duration:

5 d

Temp.:

50 °C

Initial conc. measured:

ca. 10 mg/L

Remarks:

2. pH range used for the study was 4, 7 and 9, respectively

pH:

7

Temp.:

20 °C

Remarks:

3. Other details not known

Positive controls:

not specified

Negative controls:

not specified

Transformation products:

no

Remarks:

2. No transformation product was formed and 3. Not specified

% Recovery:

99

pH:

4

Temp.:

50 °C

Duration:

5 d

Remarks on result:

other: 2. % recovery: 100%, 97.5% (average 99.0%)

% Recovery:

99.5

pH:

7

Temp.:

50 °C

Duration:

5 d

Remarks on result:

other: 2. % recovery: 99.8%, 99.2% (average 99.5%)

% Recovery:

99.7

pH:

9

Temp.:

50 °C

Duration:

5 d

Remarks on result:

other: 2. % recovery: 98.8%, 98.6% (average 98.7%)

Temp.:

50 °C

DT50:

> 5 d

Type:

not specified

Remarks on result:

other: 2. pH range used for the study was 4, 7 and 9, respectively

pH:

7

Temp.:

20 °C

DT50:

> 1 yr

Remarks on result:

other: 3. Other details not known

Details on results:

2. Test chemical was reported to be hydrolytically stable at pH 4, 7 and 9, respectively at a temperature of 50⁰C for 5 days.

3. The only functional group present is the amide group, which hydrolyzes very slowly at neutral pH.

Validity criteria fulfilled:

not specified

Conclusions:

On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be > 5 days at pH 4, 7 and 9 & at a temperature of 50⁰C, respectively or > 1 years at pH 7 & at a temperature of 20⁰C, respectively.

Executive summary:

Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the half-life of the test chemical.The studies are as mentioned below:

The half-life of the test chemical was determined at different pH range. The study was performed according to OECD Guideline 111 (Hydrolysis as a Function of pH) at a temperature of 50°C. The average percentage recovery of the test chemical after 5 days was determined to be 99.0, 99.5 and 98.7% at pH 4, 7 and 9, respectively. As no hydrolysis of test item was observed for a period of 5 days, the half-lives was determined to be > 5 days at pH 4, 7 and 9 & at a temperature of 50⁰C, respectively. Based on the half-life values, it is concluded that the test substance is not hydrolysable.

In an another study, the half-life of the test chemical was determined at pH 7.0. The study was performed at a temperature of 50°C. The only functional group present is the amide group, which hydrolyzes slowly at neutral pH. The half-life value of the test chemical was determined to be > 1 years at pH 7 & at a temperature of 20⁰C, respectively. Based on the half-life value, it is concluded that test chemical is not hydrolysable.

On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be > 5 days at pH 4, 7 and 9 & at a temperature of 50⁰C, respectively or  > 1 years at pH 7 & at a temperature of 20⁰C, respectively.

Description of key information

On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be > 5 days at pH 4, 7 and 9 & at a temperature of 50⁰C, respectively or > 1 years at pH 7 & at a temperature of 20⁰C, respectively.

Additional information

Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the half-life of the test chemical. The studies are as mentioned below:

 

The half-life of the test chemical was determined at different pH range. The study was performed according to OECD Guideline 111 (Hydrolysis as a Function of pH) at a temperature of 50°C. The average percentage recovery of the test chemical after 5 days was determined to be 99.0, 99.5 and 98.7% at pH 4, 7 and 9, respectively. As no hydrolysis of test item was observed for a period of 5 days, the half-lives was determined to be > 5 days at pH 4, 7 and 9 & at a temperature of 50⁰C, respectively. Based on the half-life values, it is concluded that the test substance is not hydrolysable.

 

In an another study, the half-life of the test chemical was determined at pH 7.0. The study was performed at a temperature of 50°C. The only functional group present is the amide group, which hydrolyzes slowly at neutral pH. The half-life value of the test chemical was determined to be > 1 years at pH 7 & at a temperature of 20⁰C, respectively. Based on the half-life value, it is concluded that test chemical is not hydrolysable.

 

On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be > 5 days at pH 4, 7 and 9 & at a temperature of 50⁰C, respectively or > 1 years at pH 7 & at a temperature of 20⁰C, respectively.