Registration Dossier
Registration Dossier
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EC number: 222-656-9 | CAS number: 3567-66-6
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
Data source
Reference
- Reference Type:
- secondary source
- Title:
- INITIAL SUBMISSION: ACUTE ORAL TOXICITY OF C.I. ACID RED 151 WITH COVER LETTER DATED 090292
- Author:
- DuPont Chem Company
- Year:
- 1 992
- Bibliographic source:
- NTRL NO: OTS0571003, 09/03/92
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as below
- Principles of method if other than guideline:
- The acute oral L50 test of C.I. Acid Red 151 in ChR-CD male rat.
- GLP compliance:
- not specified
- Test type:
- other: No data available
Test material
- Reference substance name:
- Sodium 4-(4-(2-hydroxynaphthalenylazo)phenylazo)benzenesulphonate
- EC Number:
- 229-029-9
- EC Name:
- Sodium 4-(4-(2-hydroxynaphthalenylazo)phenylazo)benzenesulphonate
- Cas Number:
- 6406-56-0
- IUPAC Name:
- sodium 4-({4-[(2-hydroxy-1-naphthyl)diazenyl]phenyl}diazenyl)benzenesulfonate
- Reference substance name:
- C.I. Acid Red 151
- IUPAC Name:
- C.I. Acid Red 151
- Details on test material:
- - Name of test material (as cited in study report):C.I. Acid Red 151- Molecular formula (if other than submission substance):C22-H15-N4-O4-S.NaC22-H16-N4-O4-S.Na- Molecular weight (if other than submission substance):455.448 g/mol- Substance type:Organic- Physical state:Solid- Purity:No data available
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- other: ChR-CD
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Doses:
- 7500, 8000, 8500 and 9500 mg/kg
- No. of animals per sex per dose:
- 10/dose
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 7 736 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Mortality observed
- Clinical signs:
- other: Belly-to-cage posture, eyes half closed, prostration, pallor, stained mouth and compound and/or metabolite(s) in feces after dosing at 9,500 mg/kg.Belly-to-cage posture, eyes half closed, lethargy, prostration, labored breathing, stained nose and mouth, s
Any other information on results incl. tables
Dose(mg/kg) | Avg. bw | Mortality ratio |
7500 | 267 | 2/10 |
8000 | 256 | 9/10 |
8500 | 266 | 9/10 |
9500 | 244 | 10/10 |
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated informationCriteria used for interpretation of results: EU
- Conclusions:
- The acute oral L50 value of C.I. Acid Red 151 is considered to be 7,736 mg/kg in male rat.
- Executive summary:
Acute oral toxicity (LD50) test ofC.I. Acid Red 151 was conducted in ChR-CD male rat. Test substancewas administered 7500, 8000, 8500 and 9500 mg/kg by intragastric intubation to four groups of ten rat.
After 14 days observation, Mortality observed 2/10 at dose 7500 mg/kg; 9/10 at 8000 and 8500 mg/kg.
Therefore,the acute oral L50 value of C.I. Acid Red 151 is considered to be 7736 mg/kg in male rat
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