Registration Dossier
Registration Dossier
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EC number: 203-615-4 | CAS number: 108-78-1
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Old publication, not according to any guidelines, insufficient description of the method.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 969
- Report date:
- 1969
Materials and methods
- Principles of method if other than guideline:
- other: BASF-test
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Melamine
- EC Number:
- 203-615-4
- EC Name:
- Melamine
- Cas Number:
- 108-78-1
- Molecular formula:
- C3H6N6
- IUPAC Name:
- 1,3,5-triazine-2,4,6-triamine
- Details on test material:
- Purity: >= 99.9 %Molecular weight: 126.13pH (aqueous solution): 7.5 - 8.0Boiling point: Sublimation at > 300 °CVapour pressure (20 °C): < 10-5 TorrFlammability: 354 °C
Constituent 1
Test animals
- Species:
- mouse
- Sex:
- male/female
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- other: Traganth
- Doses:
- 200, 400, 800, 1000, 1250, 1600 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- Surviving animals were observed for one week after exposure and then sacrificed. A post mortem examination was performed.
Results and discussion
Effect levels
- Dose descriptor:
- LD50
- Effect level:
- 800 mg/kg bw
- Mortality:
- 1600 mg/kg: All animals died within 7 days after the administration.
1250 mg/kg: 9/10 animals died within 48 hours after the administration.
1000 mg/kg: All animals died within 48 hours after the administration.
800 mg/kg: 4/10 animals died within 7 days after the administration.
400 mg/kg: All animals survived until the end of the study.
200 mg/kg: 1/10 animals died within 24 hours after the administration. - Clinical signs:
- Immediately after the administration in all animals accelerated breathing, tumbling, retracted flanks, raised fur, closed eyes. On the consecutive days huddled posture, face-down position, apathy. Recovery of the survivors 3 - 5 days after the administration.
- Gross pathology:
- deceased animals: intestinal tract, atonic ; sacrificed animals: liver, adhesions
Applicant's summary and conclusion
- Conclusions:
- LD50 = 800 mg/kg
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