Registration Dossier
Registration Dossier
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EC number: 215-607-8 | CAS number: 1333-82-0
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study is reported in summary form only, but the results support the proposed classification
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 979
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The study is a non-guideline irritation screening study.
- GLP compliance:
- no
- Remarks:
- Pre-dates GLP; screening study
Test material
- Reference substance name:
- chromtrioxid
- IUPAC Name:
- chromtrioxid
- Reference substance name:
- chromium (VI) trioxide
- IUPAC Name:
- chromium (VI) trioxide
- Details on test material:
- No further details provided
Constituent 1
Constituent 2
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Duration of treatment / exposure:
- Animals were exposed to 50 mg of the test material and observed for up to 7 days.
- Observation period (in vivo):
- 7 days
- Number of animals or in vitro replicates:
- Two
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- other: not applicable
- Time point:
- other: not applicable
- Max. score:
- 100
- Reversibility:
- not reversible
- Remarks on result:
- other: An overall score irritation is not given in the report. A maximum score of 100 has been added for completeness. The test substance was found to be corrosive.
- Irritant / corrosive response data:
- An overall score irritation is not given in the report. A maximum score of 100 has been added for completeness. The test substance was found to be corrosive.
- Other effects:
- Very marked reddening and corrosion are noted.
Any other information on results incl. tables
Results are reported very briefly (very marked reddening and corrosive effects).
Applicant's summary and conclusion
- Interpretation of results:
- other: EU GHS Cat. 1 cause serious eye damage
- Conclusions:
- The results of this study indicate that chromium trioxide is corrosive.
- Executive summary:
50 mg chromium trioxide instilled into one eye of two New Zealand White rabbits produced corrosive effects.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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