Registration Dossier
Registration Dossier
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EC number: 202-851-5 | CAS number: 100-42-5
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- adult fish: sub(lethal) effects
- Type of information:
- experimental study planned
- Justification for type of information:
- TESTING PROPOSAL ON VERTEBRATE ANIMALS
NON-CONFIDENTIAL NAME OF SUBSTANCE:
- Name of the substance on which testing is proposed to be carried out: Styrene
CONSIDERATIONS THAT THE GENERAL ADAPTATION POSSIBILITIES OF ANNEX XI OF THE REACH REGULATION ARE NOT ADEQUATE TO GENERATE THE NECESSARY INFORMATION:
- Available GLP studies: No GLP-studies available
- Available non-GLP studies: No non-GLP-studies available
- Historical human/control data: Not relevant
- (Q)SAR: No valid QSAR methods available to reliably estimate the long-term toxicity to fish for styrene
- In vitro methods: Not applicable
- Weight of evidence: No data for weight of evidence approach available
- Grouping and read-across: There is no data available for structurally similar substances and the substance is not member of a category. Thus, predicting the long-term toxicity on fish based on a read-across is not possible.
- Substance-tailored exposure driven testing: Not applicable
- Approaches in addition to above: Not applicable
- Other reasons: Not applicable
CONSIDERATIONS THAT THE SPECIFIC ADAPTATION POSSIBILITIES OF ANNEXES VI TO X (AND COLUMN 2 THEREOF) OF THE REACH REGULATION ARE NOT ADEQUATE TO GENERATE THE NECESSARY INFORMATION:
- The specific adaption possibilities of ANNEX IX are not adequate to generate the necessary information, consequently there is a data gap regarding the long-term toxicity on fish. Long-term toxicity testing on fish is a standard information requirement in ANNEX IX to REACH (Annex IX, Section 9.1.6).
FURTHER INFORMATION ON TESTING PROPOSAL IN ADDITION TO INFORMATION PROVIDED IN THE MATERIALS AND METHODS SECTION:
- Details on study design / methodology proposed: OECD Guideline 210, no further details for the planned study are available yet. - Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 210 (Fish, Early-Life Stage Toxicity Test)
- Version / remarks:
- not specified yet
- GLP compliance:
- not specified
Reference
Description of key information
A chronic fish study is planned (see Study proposal).
Key value for chemical safety assessment
Additional information
There are no chronic toxicity data available for styrene with fish. A chronic fish study is planned.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
