Registration Dossier
Registration Dossier
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EC number: 232-391-0 | CAS number: 8013-07-8
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Effect on fertility: via oral route
- Dose descriptor:
- NOAEL
- 1 000 mg/kg bw/day
Additional information
The test substance did not induce any toxic effects in parent males and females, did not disturb their capacity of reproduction and did not impair the development of the F1 offspring. Under the conditions, the highest tested dose of 1000 mg/kg bw/day was found to be the NOEL. According to Directive 67/548/EEC, no classification is warranted. According to Regulation (EC) No. 1272/2008, no classification is warranted.
Short description of key information:
A one generation study by oral route (gavage) was carried out in rats according to OECD test guideline 415.
Effects on developmental toxicity
Description of key information
An embryotoxicity/teratogenicity study by oral route was carried out in rats according to OECD guideline 414.
Effect on developmental toxicity: via oral route
- Dose descriptor:
- NOAEL
- 1 000 mg/kg bw/day
Additional information
The test substance was well tolerated by the dams at all the dose levels and was neither embryonic or teratogenic. The No Observable Adverse Effect Level is defined as 1000 mg/kg bw/day in terms of maternotoxic effects and embryofetal development.The No Observable Effect Level is defined as 1000 mg/kg bw/day in terms of maternotoxic effects and embryofetal development.
Justification for classification or non-classification
According to Directive 67/548/EEC, no classification is warranted. According to Regulation (EC) No. 1272/2008, no classification is warranted.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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