Registration Dossier
Registration Dossier
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EC number: 232-051-1 | CAS number: 7784-18-1
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
It is not possible to perform the recommended in vitro genetic toxicity studies with aluminium fluoride as it is not soluble in concentrations from 500 to 0.5 mg/mL in the standard solvents (culture medium, ethanol, and dimethyl-sulfoxide). In addition, a homogenous suspension cannot be made in these solvents; aluminium fluoride particles sink to the bottom of the bottle or test tube immediately after vortexing is stopped. Based on this information, in accordance with section 2 of REACH (Regulation (EC) No 1907/2006) Annex XI, the genetic toxicity studies (required in Annex VII section 8.4.1 and Annex VIII sections 8.4.2 and 8.4.3) do not need to be conducted as it is technically not possible to conduct the test due to the formation of precipitation at the required concentrations.
Endpoint Conclusion:
Justification for classification or non-classification
As it is not possible to perform the recommended in vitro genetic toxicity studies with the notifiable substance, it is not classified as a germ cell mutagen as data are lacking.
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