Registration Dossier
Registration Dossier
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EC number: 211-074-0 | CAS number: 629-11-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable study report which meets basic scientific principles
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 961
- Report date:
- 1961
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- Internal BASF method was used, which was in large part equivalent to OECD guideline 401
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Hexane-1,6-diol
- EC Number:
- 211-074-0
- EC Name:
- Hexane-1,6-diol
- Cas Number:
- 629-11-8
- Molecular formula:
- C6H14O2
- IUPAC Name:
- hexane-1,6-diol
- Details on test material:
- - Name of test material (as cited in study report): Hexandiol-1,6
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: mean 145 g (female), mean 172 g (male)
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 20% - Doses:
- 2500, 3200, 6400 mg/kg bw
- No. of animals per sex per dose:
- 2500 mg/kg bw: 3 male, 2 female
3200 mg/kg bw: 6 male, 4 female
6400 mg/kg bw: 2 male, 3 female - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 days (2500 and 6400 mg/kg bw), 14 days (3200 mg/kg bw)
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, mortality
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 3 000 mg/kg bw
- Mortality:
- 2500 mg/kg bw: 0/5 within 7 days
3200 mg/kg bw: 7/10 within 24 h
6400 mg/kg bw: 4/5 within 24 h; 5/5 within 7 days - Clinical signs:
- other: 2500 mg/kg bw: slight staggering within 24 h 3200 mg/kg bw: apathy within 1 h; lateral position, narcotic state, atonia, constant urination within 3 h; surviving animals showed no symptoms 6400 mg/kg bw: slight apathy and slight atonia within 1 h; lateral
- Gross pathology:
- no abnormalities found
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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