Registration Dossier
Registration Dossier
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EC number: 205-011-6 | CAS number: 131-11-3
Immunotoxicity
Administrative data
- Endpoint:
- immunotoxicity
- Remarks:
- other: in vitro test in mouse cells (lymphocytes)
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable publication, meets basic scientific principles.
Data source
Reference
- Reference Type:
- publication
- Title:
- Immunotoxicological evaluation of environmental chemicals utilizing mouse lymphocyte mitogenesis test;
- Author:
- Sakazaki H et al.
- Year:
- 2 001
- Bibliographic source:
- Journal of Health Science 47(3): 258-271
Materials and methods
- Principles of method if other than guideline:
- Method: other. Lymphocyte mitogenesis test. The growth-inhibitory effect of the test substance on the mouse splenic lymphocyte mitogenesis. Toxicity on toxicity on humoral immunity and cell-mediated immunity was evaluated.
Test material
- Reference substance name:
- Dimethyl phthalate
- EC Number:
- 205-011-6
- EC Name:
- Dimethyl phthalate
- Cas Number:
- 131-11-3
- Molecular formula:
- C10H10O4
- IUPAC Name:
- 1,2-dimethyl benzene-1,2-dicarboxylate
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- Dimethyl phthalate;
CAS-No.: 131-11-3;
no further data
Test animals
- Species:
- mouse
- Strain:
- other: C3H/He mouse for the B cell test and BALB/c mouse for the T cell test
- Sex:
- not specified
Administration / exposure
- Route of administration:
- other: Application in medium of cultured immune cells
- Vehicle:
- other: RPMI-1640 medium for cultivation of mammalian cells
Results and discussion
Any other information on results incl. tables
DMP showed no inhibitory effect on mouse lymphocyte mitogenesis of B-cells and T-cells.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
