Registration Dossier
Registration Dossier
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EC number: 264-150-0 | CAS number: 63449-39-8
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1978
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Principles of method if other than guideline:
- Repeated daily occlusive administration.
- GLP compliance:
- no
Test material
- Reference substance name:
- Paraffin waxes and Hydrocarbon waxes, chloro
- EC Number:
- 264-150-0
- EC Name:
- Paraffin waxes and Hydrocarbon waxes, chloro
- Cas Number:
- 63449-39-8
- Molecular formula:
- C18H33Cl5 C18H30Cl8 C20H36Cl6 C20H33Cl9 C25H45Cl7 C25H42Cl10 C25H29C23 C30H53Cl9 C30H49Cl13 C30H35Cl27
- IUPAC Name:
- Paraffin waxes and Hydrocarbon waxes (C18 and longer), chloro
- Details on test material:
- C22-26; 42% Cl (liquid) (stabilised). Meflex DC016. Stabiliser: 0.2% epoxy soya bean oil, 0.3% Lubrizol LZ55A. 0.3% polyethylene glycol and 0.2% Nonox WSL.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 6 repeated occlusive, topical applications (0.1ml)
- Duration of treatment / exposure:
- 12 days with 6 alternate decontaminations.
- Observation period:
- No data
- Number of animals:
- 3
Results and discussion
In vivo
Results
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 4 application
- Score:
- < 1
- Reversibility:
- fully reversible
- Remarks on result:
- other: slight erythema and desquamation observed in 1 of 3 rats after 4th application.
Any other information on results incl. tables
Slight erythema and desquamation was observed in 1 out of 3 rats after the 4th application. The effect was not present by the final day of the test. It was concluded that the substance was practically non-irritant
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Slight erythema and desquamation was observed in 1 out of 3 rats after the 4th application. The effect was not present by the final day of the test. It was concluded that the substance is not classifiable as an irritant.
- Executive summary:
Slight erythema and desquamation was observed in 1 out of 3 rats after the 4th application. The effect was not present by the final day of the test. It was concluded that the substance is not classifiable as an irritant.
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