Registration Dossier
Registration Dossier
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EC number: 200-467-2 | CAS number: 60-29-7
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study without detailed documentation.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- publication
- Title:
- Range-finding toxicity data: List VI
- Author:
- Smyth, H.F., Carpenter, C.P., Weil, C.S., Pozzani, U.C., Striegel, J.A.
- Year:
- 1 962
- Bibliographic source:
- Am. Ind. Hyg. Assoc. J., 1962, 23, 95-107
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Principles of method if other than guideline:
- Similar to the one-day cuff method described by Draize (Draize, J.H., Woodard, G., Calvary, H.O., J. Pharmacol. Exp. Therap., 1944, 82, 377).
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Diethyl ether
- EC Number:
- 200-467-2
- EC Name:
- Diethyl ether
- Cas Number:
- 60-29-7
- Molecular formula:
- C4H10O
- IUPAC Name:
- diethyl ether
- Test material form:
- liquid: volatile
- Details on test material:
- No details on the test material are available.
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Type: albino
- Weight at study initiation: 2.5-3.5kg
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: trunk - Duration of exposure:
- 24 hours
- Doses:
- Logarithmic series, differing by a factor of 2
- No. of animals per sex per dose:
- 4 animals per dose
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Statistics:
- LD50 and fiducial range estimated by the method described by Thomson (Thomson, W.R., Bacteriol. Rev., 1947, 11, 115) and Weil (Weil, C.S., Biometrics, 1952, 8, 249).
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 20 000 mg/kg bw
Applicant's summary and conclusion
- Executive summary:
The work of this group pre-dates range finding toxicity guidelines and provided much of the basis for their development. Their results are cited by many subsequent authoritative review bodies and are often found in SIDS and SIAR documents via secondary references. Therefore, these results are deemed reliable.
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