Registration Dossier
Registration Dossier
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EC number: 203-686-1 | CAS number: 109-60-4
Carcinogenicity
Administrative data
Description of key information
Metabolites
Propan-1-ol: not carcinogenic
Acetic acid: not carcinogenic
Key value for chemical safety assessment
Carcinogenicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Carcinogenicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Carcinogenicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
No indication for carcinogenetic activity of propyl acetate since the metabolites propan-1-ol and acetic acid reveal no carcinogenic potential.
Additional information
No data available for propyl acetate.
Propyl acetate is metabolized to propan-1-ol and acetic acid. Valid carcinogenicity studies of propan-1-ol did not reveal a carcinogenic potential of this substance. There is no indication for carcinogenicity given for acetic acid from available data (in vitro mutagenicity, oral repeated dose, short- and long-term up to 8 month).
Read across justification to propan-1-ol and n-butyl acetate for filling data gaps of n-propyl acetate:
As indicated by toxicokinetic studies (see chapter on toxicokinetics, metabolism and distribution), n-propyl acetate is rapidly hydrolyzed to propan-1-ol and acetate (acetic acid). Available data on propan-1-ol is therefore suitable for filling data gaps of n-propyl acetate.
N-propyl acetate and n-butyl acetate differ structurally by only one –CH2 group and both substances have a similar toxicological profile. The available data for n-butyl acetate is therefore suitable for filling the data gaps of n-propyl acetate due to structural similarities. See IUCLID section 13 for a detailed read across justification.
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