Registration Dossier
Registration Dossier
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EC number: 204-616-2 | CAS number: 123-30-8
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1980
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Secondary source
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Toxikologische Bewertung – p-Aminophenol.
- Author:
- Berufsgenossenschaft der chemischen Industrie BCI, Heidelberg, Germany
- Year:
- 1 995
- Bibliographic source:
- Toxicological Evaluation, 15, 337-381
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EPA OPPTS 870.1200 (Acute Dermal Toxicity)
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 4-aminophenol
- EC Number:
- 204-616-2
- EC Name:
- 4-aminophenol
- Cas Number:
- 123-30-8
- Molecular formula:
- C6H7NO
- IUPAC Name:
- 4-aminophenol
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- other: tragacanth
- Details on dermal exposure:
- TEST SITE
- Area of exposure: dorsal skin (clipped hair)
TEST SITE
- Area of exposure: intact and abraded skin
TEST MATERIAL
- Concentration (if solution): 50% aqueous suspension with tragacanth - Duration of exposure:
- 24 hr
- Doses:
- 2000. 4000 and 8000 mg/kg bw
- No. of animals per sex per dose:
- 4 animals per dose
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 8 000 mg/kg bw
- Mortality:
- All animals survived.
- Clinical signs:
- other: Deep green-brown discoloration of application site was observed, which later changed to yellowish-brown.
- Gross pathology:
- No. effect was observed.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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