Registration Dossier
Registration Dossier
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EC number: 245-442-7 | CAS number: 23128-74-7
Specific investigations: other studies
Administrative data
- Endpoint:
- endocrine system modulation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 13.11.2012 - 23.11.2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: recent study conducted according to reliable in-house protocol
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: according to E. Routledge and J.P. Sumpter (1996)
- Principles of method if other than guideline:
- The aim of the study was to determine the estrogenic and antiestrogenic potential of (4nonylphenoxy) acetic acid. The yeast cells used in the yeast estrogen screening (YES) assay have been stably transformed with genes for the human estrogen receptor a and the ß-galactosidase reporter gene. Estrogenic as weil as antiestrogenic potentials of the test substances mediated by receptor binding or blocking can be determined using this assay, respectively.
- GLP compliance:
- no
- Type of method:
- in vitro
Test material
- Reference substance name:
- N,N'-hexane-1,6-diylbis[3-(3,5-di-tert-butyl-4-hydroxyphenylpropionamide]
- EC Number:
- 245-442-7
- EC Name:
- N,N'-hexane-1,6-diylbis[3-(3,5-di-tert-butyl-4-hydroxyphenylpropionamide]
- Cas Number:
- 23128-74-7
- Molecular formula:
- C40H64N2O4
- IUPAC Name:
- N,N'-hexane-1,6-diylbis[3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanamide]
- Details on test material:
- Storage Conditions: Room Temperature
Constituent 1
Administration / exposure
- Vehicle:
- DMSO
Results and discussion
- Details on results:
- ln this study, the test substance showed no estrogenic activity in comparison to 17ß-estradiol. ln this study, the test substance showed no antiestrogenic activity from about 10-5 mol/L in comparison to hydroxytamoxifen. Precipitations of the test substance were observed at a concentration of 10E-4 mol/L.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
