Phosphorus pentachloride

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

weight of evidence

Study period:

1973

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Published study

Cross-reference

Reason / purpose for cross-reference:

reference to same study

Data source

Reference

Reference Type:

publication

Title:

Comparative Toxicity of Chloride Compounds of Phosphorus (POCl3, PCl3, PCl5) in single and repeated exposures

Author:

Molodkina NN

Year:

1973

Bibliographic source:

Toksikologiya Novykh Prom, Khim, Veshch. 13: 107-114

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Deviations:

not specified

Principles of method if other than guideline:

No further information

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Phosphorus pentachloride

EC Number:

233-060-3

EC Name:

Phosphorus pentachloride

Cas Number:

10026-13-8

Molecular formula:

PCl5

IUPAC Name:

pentachloro-λ⁵-phosphane

Details on test material:

Acute oral toxicity study: estimation of LD50 in the rat

Test animals

Species:

rat

Strain:

not specified

Sex:

not specified

Details on test animals or test system and environmental conditions:

The test substance was administered in vegetable oil to 6 animals.

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

vegetable oil

Details on oral exposure:

The substance was administered at each dose to six animals in the form of a suspension in vegetable oil in order to determine the lethal dose of the test substance on introduction into the stomach.

Doses:

A range of doses were administered to the rats in the form of a suspension in vegetable oil.

No. of animals per sex per dose:

6 animals per dose; sex not specified

Control animals:

no

Details on study design:

Rats weighing 180-200 g were used to determine the lethal dose of the test substance on introduction into the stomach. The substance was administered at each dose to 6 animals in the form of suspensions in vegetable oil.

Results and discussion

Preliminary study:

No preliminary study.

Effect levels

Sex:

not specified

Dose descriptor:

LD50

Effect level:

ca. 600 mg/kg bw

Based on:

test mat.

95% CL:

ca. 571 - ca. 630

Mortality:

Not stated

Clinical signs:

other: Clinical signs included depression, loss of coordination in movements, apathy, adynamia and sometimes the appearance of an ichorous discharge from the eye. The respiration was reduced to 50-80 per minute. Twenty to 40 minutes after administration at

Gross pathology:

In the autopsies, the lungs were of a bright red color, the liver was dark brown and it was full of blood when sectioned. The stomach was swollen and there were heavy blood infusions on the mucous membrane.

Other findings:

No further findings.

Any other information on results incl. tables

The acute oral LD50 of the test substance phosphorus pentachloride in the rat was determined to be 600 mg/kg bw under the conditions of this study. Signs of toxicity (depression, loss of coordination, apathy, lack of movement and ocular discharge) were observed. Cyanosis was apparent prior to death. Necropsy revealed bright red lungs, dark brown liver and haemorrhagic mucous membranes.

Applicant's summary and conclusion

Interpretation of results:

other: Acute toxicity cat. 4

Remarks:

Criteria used for interpretation of results: EU

Conclusions:

The acute oral LD50 of the test substance phosphorus pentachloride in the rat was determined to be 600 mg/kg bw under the conditions of this study.

Executive summary:

Rats were gavaged with a single dose of phosphorus pentachloride at various dose levels, suspended in vegetable oil. The acute oral LD50 of the test substance was found to be 600 mg/kg bw.The substance is classified acute toxicity cat.4 according to the CLP regulation (EC N.1272/2008)