Triphenylphosphine

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

May - September 1951

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Screening test; discrepancy between documented test parameters and standard methods, but scientifically acceptable.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1952

Report date:

1952

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

BASF-internal standard method, conducted before OECD 423 was in place
- Principle of test: The acute oral toxicity to rats was evaluated by a single administration of 10% oily suspension, equivalent to doses of 250, 500, 1000 and 2000 mg/kg test material. Afterwards, the animals were observed 8 days for mortality and syptoms of acute intoxication. Dead animals, time to death and symptoms of acute intoxication were recorded. The mean lethal dose was determined.

GLP compliance:

no

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Triphenylphosphine

EC Number:

210-036-0

EC Name:

Triphenylphosphine

Cas Number:

603-35-0

Molecular formula:

C18H15P

IUPAC Name:

triphenylphosphine

Test material form:

solid: crystalline

Specific details on test material used for the study:

TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Final dilution of a suspended solid: 10 %

FORM AS APPLIED IN THE TEST (if different from that of starting material): oily suspension

Test animals

Species:

rat

Strain:

other: albino

Sex:

not specified

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

olive oil

Details on oral exposure:

VEHICLE
- Concentration in vehicle: 10%

Doses:

250, 500, 1000, 2000 mg/kg bw

No. of animals per sex per dose:

- sex unspecified, 5-10 animals per dose group
- 250 mg/kg: 5 animals
- 500 mg/kg: 10 animals
- 1000 mg/kg: 10 animals
- 2000 mg/kg: 5 animals

Control animals:

no

Details on study design:

- Duration of observation period following administration: 8 days
- Frequency of observations: daily

Results and discussion

Effect levels

Sex:

not specified

Dose descriptor:

LD50

Effect level:

700 mg/kg bw

Remarks on result:

other: 1/10 dead at 500 mg/kg; 10/10 dead at 1000 mg/kg

Mortality:

No mortality at 250 mg/kg bw, but 1/10 at 500 mg/kg and 100% at doses > 1000 mg/kg. Death occured within 1 - 4 days after application.

Clinical signs:

other: Animals that died showed apathy, impaired balance and inappetence. No clinical findings in all surviving animals.

Any other information on results incl. tables

Table 1: Mortality

Dose [mg/kg]	Number of animals	Dead animals	Time to death [days]
2000	5	5/5	2-3
1000	10	10/10	1-4
500	10	1/10	2
250	10	0/5	-

Applicant's summary and conclusion

Interpretation of results:

Category 4 based on GHS criteria

Conclusions:

LD50 = 700 mg/kg

Executive summary:

The acute oral toxicity to rats was evaluated according to a BASF-internal standard method. Therefore, a single administration of 10% oily suspension, equivalent to doses of 250, 500, 1000 and 2000 mg/kg test material was undertaken. Afterwards, the animals were observed 8 days for mortality and poisoning syptoms. No mortality at 250 mg/kg bw, but 1/10 at 500 mg/kg and 100% at doses > 1000 mg/kg. Death occurred within 1 - 4 days after exposure. Animals that died showed apathy, impaired balance and inappetence. Surviving animals showed no clinical findings. The mean lethal dose was determined to be 700 mg/kg.