Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 231-831-9 | CAS number: 7758-05-6
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Short description of key information on bioaccumulation potential result:
The toxicokinetics of potassium iodate have been investigated by H Burgi, etal and the study has been reported in the end point. Following oral administration and intra-arterial infusion, potassium iodate is found to be rapidly absorbed and is excreted predominantly in the urine. Based on the study reported it indicates that there is no potential for bioaccumulation.
Key value for chemical safety assessment
Additional information
Radiolabelled iodate (131I) was administered via i.v. injection to rabbits (no further experimental details available) (Grant, 1974). Radiolabel was absorbed rapidly into aqueous and vitreous humours of the eye (time unknown). Any radiolabel remaining in blood persisted for many hours and was gradually reduced by the liver to iodide. [Klimisch code: 4]
Rats and rabbits (strain unknown) were administered 0.75-1 μg iodine via the oral route or intraperitoneally. Radioiodine was extensively distributed and found in the liver, kidney, brain, heart, muscle, small intestine, stomach, testes, submaxillary gland, skin, hair and thyroid (values unknown). Tissue distribution was the same for both iodine and iodate (Taurog et al., 1966). [Klimisch code: 3]
When added to animal feed, iodate increases the level of iodine in eggs and milk (animal species unknown) (Burgi et al., 2001). No further details are available. [Klimisch code: 4]
Iodate was administered via i.v. injection to rats (dose and strain unknown). Iodate in blood was reduced to iodide within 40 minutes (Burgi et al., 2001). No further details are available. [Klimisch code: 4]
The reduction of iodate has been shown to be a non-enzymatic process and depends on the availability of sulfhydryl groups. It is inhibited by N-ethyl-maleimide (Burgi et al., 2001). No further details are available. [Klimisch code: 4]
Dogs (strain unknown) were fed gelatine capsules containing a single dose of 200 mg potassium iodate/kg bw. Urine from these dogs contained iodide and iodate (Burgi et al., 2001) (no further details are available). This suggests that iodate is converted to iodine (extent unknown) and the urine is a primary route of excretion (extent unknown). [Klimisch code: 4]
Iodate is rapidly absorbed and extensively distributed. It is metabolised via a non-enzymatic process, with a proportion of the available iodate converted to iodine. Iodate is excreted via the kidneys.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
