Registration Dossier
Registration Dossier
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EC number: 202-879-8 | CAS number: 100-69-6
Endpoint summary
Administrative data
Description of key information
As 2VP is corrosive to the skin and eye, the risk assessment will proceed in a qualitative manner. Risk management measures as recommended will protect workers from corrosive effects of this substance.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
The study of Barr and Wnorowski, 1994, of undiluted 2VP applied for 1 hour to the shaved skin of New Zealand White Rabbits, indicated that the skin showed signs of necrosis within 48 hours. Corrosion was also noted in other studies on skin irritation. In an old non-guideline study, 2VP was instilled into the eyes of three rabbits, and found to be a strong irritant with evidence of corneal opacity and adnexa in all animals tested. No data is available for respiratory irritation; the determination of corrosion for eye and skin result in a default GHS classification of H071, corrosion to the respiratory tract.
Effects on skin irritation/corrosion: corrosive
Effects on eye irritation: corrosive
Effects on respiratory irritation: irritating
Justification for classification or non-classification
2-Vinylpyridine is corrosive to the skin of rabbits after exposures of 1 hour. The substance is classified as a Category 1B corrosive as it causes corrosion when applied to skin for a time period of between 3 minutes and 1 hour. 2-Vinylpyridine caused severe irritation to the eye resulting in irreversible damage to the cornea, and so is classified as causing serious eye damage, Category 1. There is no vaide data on toxicity by the inhalation route of administration. Because the mechanism of action of 2-vinylpyridine involves corrosivity, the compound is classified as H071, corrosive to the respiratory tract.
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