Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 201-051-3 | CAS number: 77-71-4
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Effect on fertility: via oral route
- Dose descriptor:
- NOAEL
Additional information
Two generation reproduction toxicity in CD rats - Neeper-Bradley (1994)
In conclusion, continuous exposure to DMH in the diet for two generations did not result in parental toxicity or adverse effects on reproduction or reproductive tissues at dietary concentrations as high as 20000 ppm. Small increases in parental food consumption and body weight and slight transient decreases in offspring body weight were observed at the 20000 ppm dose level. The no-observed-effect level (NOEL) for parental animals and offspring in this study was 6000 ppm. The NOEL for reproductive effects was at least 20000 ppm which was equivalent to
Short description of key information:
A two generation reproductive toxicity study is available. The substance DMH is not a reproductive toxin but there may be an effect on lactation. NOEL (reproductive effects) > 20000 ppm
Effects on developmental toxicity
Description of key information
The substance is not a developmental toxin as no maternal toxic effects and no teratogenic/embryotoxic effects were observed.
Effect on developmental toxicity: via oral route
- Dose descriptor:
- NOAEL
- 1 000 mg/kg bw/day
Additional information
Test substance DMH was estimated of not displaying any developmental toxicity effects or teratogenic/embryotoxic effects in all three developmental studies.
Justification for classification or non-classification
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
