Registration Dossier
Registration Dossier
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EC number: 309-912-6 | CAS number: 101357-15-7
Endpoint summary
Administrative data
Description of key information
Two chronic ecotoxicity studies are available on fish and Daphnia. The results are sumamrised as follows:
Daphnia:
A 21-day toxicity test was conducted on the substance, with the Daphnid, Daphnia magna Straus. This test determines the adverse effects of the test substance on survival, reproduction, and growth of the Daphnid. The life-cycle test was conducted at 21 degrees C with time-weighted mean measured test concentrations of 0.00023, 0.00058, 0.0022, 0.0059 and 0.021 mg/l. Each exposure concentration consisted of ten replicates: to evaluate the effects on reproduction, growth and mortality. A toxic response was not achieved through the highest exposure concentration of 0.021 mg/L; therefore, the NOEC and NOECs for survival, reproduction were 0.021 mg/L. In addition the 21 -Day EC50 (immobilisation and reproduction) were estimated to be greater than 0.021 mg/L.
Fish:
The effects of exposure to early life stage fish was assessed in accordance with the standardised guidelines OECD 210,EPA OCSPP 850.1400and ASTMStandard E 1241-05, underGLP conditions.
The study was awarded a reliability score of 1 in accordance with the criteria set forth by Klimisch et al. (1997).
During the study, Fathead minnows (Pimephales promelas) were exposed to the test material at mean measured concentrations of 0.0044, 0.0074, 0.015, 0.037 and 0.072 mg/L under flow-through conditions for 32 days (a 4-day hatching period plus a 28-day post-hatch growth period). There were no statistically significant treatment-related effects on mean time to hatch, hatching success, survival or growth at time-weighted mean measured concentrations of ≤ 0.072 mg/L, in comparison to the pooled control.
Since the negative control and solvent control data were found to be statistically different (p ≤ 0.05) for the growth endpoints, the treatment group data were compared to the solvent control alone, per OECD guidance. In comparison to the solvent control, there were no statistically significant decreases in growth, measured as total length, wet weight and dry weight, at time-weighted mean measured concentrations of ≤ 0.072 mg/L.Under the conditions of the study, the NOEC of the test material was 0.072 mg/L. The LOEC was > 0.072 mg/L.
Additional information
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