Registration Dossier
Registration Dossier
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EC number: 226-859-3 | CAS number: 5515-83-3
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
- Study period:
- May, 2010
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: According to the prediction of toxicity delivered by the software Tox Boxes 2.9, Acute Toxicity overview indicates value with moderate/borderline reliability index.
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- In silico prediction.
Tox Boxes 2.9 is the in house software for the prediction of basic toxicity endpoints in chemicals. Predictions are made
analyzing the chemical structure and based upon large validated databases and QSAR models, in combination with expert
knowledge of organic chemistry and toxicology. - GLP compliance:
- no
- Test type:
- other: In silico prediction.
Test material
- Reference substance name:
- Ethyl 3-(diethylamino)propionate
- EC Number:
- 226-859-3
- EC Name:
- Ethyl 3-(diethylamino)propionate
- Cas Number:
- 5515-83-3
- Molecular formula:
- C9H19NO2
- IUPAC Name:
- ethyl 3-(diethylamino)propanoate
Constituent 1
Test animals
- Species:
- other: rat/mouse
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
Results and discussion
Effect levelsopen allclose all
- Dose descriptor:
- LD50
- Effect level:
- 860 mg/kg bw
- Remarks on result:
- other: Acute toxicity overview in rat indicates for DL50 value a moderate reliability index.
- Dose descriptor:
- LD50
- Effect level:
- 1 900 mg/kg bw
- Remarks on result:
- other: Acute toxicity overview in mouse indicates for DL50 value a borderline reliability index.
Applicant's summary and conclusion
- Conclusions:
- LD50 oral mouse = 1900 mg/kg (borderline RI)
LD50 oral rat = 860 mg/kg (moderate RI)
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