Registration Dossier
Registration Dossier
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EC number: 680-002-1 | CAS number: 145022-44-2
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
No signs of systemic toxicity were noticed during general observation.
When applied undiluted or as 50% and 25% solutions in 70% ethanol, the test substance did not induce a biologically relevant (no increase above the cut off Stimulation Index of 3) increase of 3H-thymidine incorporation into the cells from the auricular lymph nodes or in lymph node cell counts (no increase to 1.5 fold or above of control value = stimulation index (SI) ≥ 1.5). In addition, there were no relevant increases in lymph node weights or ear weights. Some statistically significant increases in 3H-thymidine incorporation, cell counts, lymph node weights and ear weight occurred without biological relevance or concentration relation.
Thus it is concluded that EMIM Triflat does not exhibit a skin sensitizing potential in the Murine Local Lymph Node Assay under the test conditions chosen.
Migrated from Short description of key information:
EMIM Triflat does not exhibit a skin sensitizing potential in the Murine Local Lymph Node Assay under the test conditions chosen.
Justification for classification or non-classification
Based on the data received from the LLNA, no classification as skin sensitizer according to the criteria of EU Directive 67/548/EEC and EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No 1272/2008 for EMIM Triflat is warranted.
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