Registration Dossier
Registration Dossier
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EC number: 210-848-5 | CAS number: 624-48-6
Toxicity to terrestrial arthropods
Administrative data
- Endpoint:
- toxicity to terrestrial arthropods: short-term
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well documented publication which meets basic scientific principles
Data source
Reference
- Reference Type:
- publication
- Title:
- INSECTICIDAL COMPOUNDS AGAINST DROSOPHILA MELANOGASTER FROM CORNUS OFFICINALIS SIEB. ET ZUCC.
- Author:
- MITSUO MIYAZAWA, JUN ANZAI, JUN FUJIOKA and YUKIO ISIKAWA
- Year:
- 2 003
- Bibliographic source:
- Natural Product Research 17(5): 337¿339
Materials and methods
- Principles of method if other than guideline:
- Bioassay for insecticidal activity against larvae of D. melanogaster:
Larva fed with artificial diet containing test compound - GLP compliance:
- not specified
- Application method:
- oral
Test material
- Reference substance name:
- Dimethyl maleate
- EC Number:
- 210-848-5
- EC Name:
- Dimethyl maleate
- Cas Number:
- 624-48-6
- Molecular formula:
- C6H8O4
- IUPAC Name:
- dimethyl (Z)-but-2-enedioate
- Details on test material:
- - Name of test material (as cited in study report): dimethyl malate, colorless oil
- Analytical purity: no data
Constituent 1
Test organisms
- Test organisms (species):
- Drosophila melanogaster
- Animal group:
- Diptera (fruit fly (small))
- Details on test organisms:
- About 100 adults from colonies of D. melanogaster were introduced into the new culture bottle and
allowed to oviposit for 3 h (25°C and RH>60%). Ten new eggs were used in each of the three replicates.
Study design
- Study type:
- laboratory study
- Total exposure duration:
- 8 d
Test conditions
- Test temperature:
- 25°C
- Humidity:
- RH>90%
Results and discussion
Effect concentrations
- Duration:
- 8 d
- Dose descriptor:
- LC50
- Effect conc.:
- 6.15 other: mmol/mL
- Conc. based on:
- other: diet concentration
- Basis for effect:
- mortality
Any other information on results incl. tables
Insecticidal activity against larvae of D. melanogaster was demonstrated: dimethyl maleate gave the LC50 value of 6.15 mmol/mL of diet concentration. Acute toxicity against adults of D. melanogaster, dimethyl maleate had the insecticidal activity, with the LD50 value of 21.5 mg/adult.
Applicant's summary and conclusion
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