Registration Dossier
Registration Dossier
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EC number: 200-935-6 | CAS number: 76-12-0
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- other: discussion based on literature data
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The source is considered reliable since the reported information is based on a review of existing peer-reviewed scientific literature by committees of experts in public health and related sciences.
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- 1,1,2,2-TETRACHLORO-1,2-DIFLUOROETHANE
- Author:
- American Conference of Industrial Hygienists (ACGIH)
- Year:
- 2 008
- Bibliographic source:
- 1,1,2,2-Tetrachloro-1,2-Difluoroethane: TLV® Chemical Substances 7th Edition Documentation ACGIH® Publication
- Reference Type:
- publication
- Title:
- Renal toxicity studies of selected halogenated ethanes administered by gavage to F344/N rats.
- Author:
- Buche JR
- Year:
- 1 996
- Bibliographic source:
- NTP Toxicology Program, Toxicology Report Series 45, NIH Pub 96-3935. Online at: http://ntp.niehs.nih.gov/ntp/htdocs/st_rpts/tox045.pdf
Materials and methods
- Principles of method if other than guideline:
- Ames test
- GLP compliance:
- not specified
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- 1,1,2,2 -tetrachloro-1,2 –difluoroethane
- IUPAC Name:
- 1,1,2,2 -tetrachloro-1,2 –difluoroethane
- Reference substance name:
- Tetrachloro-1,2-difluoroethane
- EC Number:
- 200-935-6
- EC Name:
- Tetrachloro-1,2-difluoroethane
- Cas Number:
- 76-12-0
- Molecular formula:
- C2Cl4F2
- IUPAC Name:
- 1,1,2,2-tetrachloro-1,2-difluoroethane
- Test material form:
- not specified
- Details on test material:
- Name of test material (as cited in study report):
1,1,2,2-tetrachloro-1,2-difluoroethane, CFC-112; 1,2-DIfluoro-1,1,2,2-tetrachloroethane; Halocarbon 112; Refrigerant 112
Constituent 1
Constituent 2
Method
Species / strain
- Species / strain / cell type:
- S. typhimurium, other: not specified
- Metabolic activation:
- not specified
Results and discussion
Test results
- Species / strain:
- S. typhimurium, other: not specified
- Metabolic activation:
- not specified
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
- Conclusions:
- 1,1,2,2 -tetrachloro-1,2-difluoroethane was reported to be weakly positive when tested in Salmonella Typhimurium.
- Executive summary:
The American Conference of Governmental Industrial Hygienists(ACGIH) is a professional association of industrial hygienists and practitioners of related professions. One of the goals of the association is to provide information and guideline on exposure limits of substances in order to advance worker protection and to this purpose,data deriving from scientific literature were rewieved.
ACGIH information is based on a review of existing peer-reviewed scientific literature by committees of experts in public health and related sciences.
The result of an Ames Test is reported. According to the result, 1,1,2,2 -tetrachloro-1,2-difluoroethane appeared to be weakly positive when tested in Salmonella Typhimurium.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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