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EC number: 285-533-9 | CAS number: 85116-81-0
Toxicity to soil macroorganisms except arthropods
Administrative data
Link to relevant study record(s)
Description of key information
NOEC (56d) >= 1000 mg/kg dw (Eisenia fetida, OECD 222); read-across
Key value for chemical safety assessment
Additional information
Since no studies investigating the toxicity to soil macroorganisms of Fatty acids, C14 -18 and C16 -18 -unsaturated, esters with neopentyl glycol (CAS No. 85116 -81 -0) are available, in accordance to Regulation (EC) No. 1907/2006 Annex XI, 1.5 a read across to the structurally similar category memberss 2,2-dimethyl-1,3-propanediyl dioleate (CAS No. 42222-50-4) and Heptanoic acid, ester with 2,2-dimethyl-1,3-propanediol (CAS No. 68855-18-5) is conducted. Further justification is given within the endpoint summary in IUCLID chapter 6.3 and within the category justification in IUCLID section 13.
The key study conducted with 2,2-dimethyl-1,3-propanediyl dioleate (CAS No. 42222-50-4) was performed according to OECD Guideline 222 and GLP (Amsel, 2013). The test organism Eisenia fetida was exposed to the nominal test concentrations of 62.5, 125, 250, 500 and 1000 mg/kg soil dw for 56 days. No significant effects on reproduction were observed, and the NOEC was reported to be ≥ 1000 mg/kg dw.
The key study conducted with Heptanoic acid, ester with 2,2-dimethyl-1,3-propanediol (CAS No. 68855-18-5) was performed as a limit test according to OECD Guideline 207 and GLP (Harris, 2013). The test organism Eisenia fetida was exposed to the nominal test concentration of 1000 mg/kg soil dw for 14 days. No mortality occurred during the study, and the LC50 was reported to be > 1000 mg/kg dw.
Thus, based on the above mentioned results, and due to the structural similarities and a consistent ecotoxicological/environmental fate profile of the substances, as are explained within the overall endpoint summary in IUCLID section 6.1 and in the category justification, it can be concluded that the toxicity of Fatty acids C14-18 and C16-18 unsatd, esters with neopentyl glycol to terrestrial macroorganisms is very low.
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