Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: basic data given

Data source

Reference
Reference Type:
publication
Title:
No information
Author:
Smyth, H.F., Jr. et al.
Year:
1962
Bibliographic source:
Am. Ind. Hyg. Assoc. J. 23, 95 - 107

Materials and methods

Principles of method if other than guideline:
Penetration of rabbit skin is estimated by a technique closely skin to the one-day cuff method of Draize and associates.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
1,2-epoxybutane
EC Number:
203-438-2
EC Name:
1,2-epoxybutane
Cas Number:
106-88-7
Molecular formula:
C4H8O
IUPAC Name:
2-ethyloxirane

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
male

Administration / exposure

Type of coverage:
occlusive
Details on dermal exposure:
Observation period: 14 d
Duration of exposure:
24 h
No. of animals per sex per dose:
4
Control animals:
not specified
Statistics:
no data

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
> 1 500 - < 2 950 mg/kg bw

Applicant's summary and conclusion