Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 201-058-1 | CAS number: 77-78-1
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Additional information
Fertility
There are neither data on fertility nor on effects on male and female reproductive organs after
repeated exposure to DMS.
Short description of key information:
EU RISK ASSESSMENT – DIMETHYL SULPHATE
Effects on developmental toxicity
Additional information
Developmental toxicity
In a teratogenicity study, pregnant rats (25 per dose group) were exposed nose only to 0, 0.5, 3.7, or 7.9 mg/m3DMS, 6 hours per day during day 6-15 of gestation (Alvarez et al.,1997). In pregnant rats exposed to 3.7 and 7.9 mg/m3a decrease in food consumption and weight gain was reported.
The NOAEL for maternal toxicity was established at 0.5 mg/m3. No significant differences in malformations and variations were reported between the fetuses in the control and the experimental groups. At the highest concentration tested, a very slight decrease of fetal weights is reported.
Therefore it is concluded that a NOAEL of 7.9 mg/m3for developmental effects can be derived.
In a publication of Molodkina et al., it is stated that repeated inhalative exposure to 2.64±0.43 and 0.29±0.02 mg/m3of male and female rats for 4 months did not induce toxic effects on reproductive organs, spermatogenesis and sperm morphology. In addition, following repeated exposure of pregnant Wistar rats, SHK- and CBAxC57BC/GI mice to DMS at concentrations of 0.46±0.05, 12.6±2.2, 20.8±4.7 mg/m3(CBA mice) over the whole gestation period (sacrifice of rats on day 21, sacrifice of mice on day 18) no embryotoxic effects were detected in rats and SHK mice at 0.29±0.02 and 2.69±0.43 mg/m3. In CBAxC57BC/GI mice DMS produced an increase in preimplantation and postimplantation loss (20.5 to 29.1%, control: 11.8%, no further details) (Molodkina et al., 1986). The very limited reporting of study design and results makes the evaluation of the study impossible and it has not be used for risk characterisation.
Conclusion
It is concluded that DMS only induced slight developmental toxicity after inhalation at maternal toxic concentrations.
Justification for classification or non-classification
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
