Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-176-9 | CAS number: 104-12-1
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
The toxicity of 1-amino-4-chlorobenzene towards the growth of Scenedesmus subspicatus after a test duration of 72 h was investigated (Kuehn und Pattard, 1990) according to DIN 38 412, Part 9. The extinction value of monochromatic radiation at a wave length of 578 nm was used to measure the cell concentration. Growth curves for each tested concetration and control were established followed by the calculation of growth rates for samples showing exponential growth during the test duration. On the basis of the mentioned conditions, an EC50 of 6.3 mg/L was determined.
4-Chlorophenyl isocyanate is know to rapidly hydrolyse forming 1-amino-4-chlorobenzene as only hydrolysis product with a half-live of 7.3 h. With respect to a test duration of 72 h, 4-chlorophenyl isocyanate would be completely degraded and observed effects are rather caused by the hydrolysis product than by the parent substance. Thus, the effect of 1-amino-4-chlorobenzene was chosen to characterize the ecotoxicological potential of 4-chlorophenyl isocyanate towards algae.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
