Registration Dossier
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EC number: 921-836-0 | CAS number: 1190402-12-0
Toxicity to soil macroorganisms except arthropods
Administrative data
Link to relevant study record(s)
Description of key information
NOEC (8 wk) ≥ 1000 mg/kg soil dw for Eisenia fetida (OECD 222)
Key value for chemical safety assessment
Additional information
As no valid study is available for assessing the toxicity to soil macroorganisms of Mixed esters of fatty acid C16 and C16-C18-unsatd. with adipic acid and pentaerythritol, in accordance to Regulation (EC) No. 1907/2006 Annex XI, 1.5 Grouping of substances, a read-across to the structurally related category member Fatty acids, C16-18 and C18-unsatd., mixed esters with adipic acid and trimethylolpropane (CAS No. 91001-61-5) was conducted. The read across is justified due to a) the structural similarity of the category members and b) similar physico-chemical properties resulting in a similar environmental fate and ecotoxicity profile. Further justification is given within the endpoint summary 6.1 and within the category justification section 13.
The study with Fatty acids, C16-18 and C18-unsatd., mixed esters with adipic acid and trimethylolpropane (CAS No. 91001-61-5) was performed under GLP and according to OECD Guideline 222 using the earthworm Eisenia foetida as test organism (Winkelmann, 2013). This test was conducted using artificial soil. No mortality or significant weight changes were observed in the control and the treatments during the test period of 4 weeks. Furthermore, no effects in reproduction up to the highest test concentration were observed. Based on reproduction the NOEC (8 weeks) was determined to be 1000 mg/kg dw soil.
Thus, based on the above mentioned results, and due to the structural similarities and a consistent ecotoxicological/environmental fate profile of the substances, as are explained with in the overall endpoint summary in IUCLID chapter 6.1, it can be concluded that toxicity of Mixed esters of fatty acid C16 and C16-C18-unsatd. with adipic acid and pentaerythritol to soil macororgansims is unlikely.
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